RAMANATHAN C.R Associate Professor

Profile Picture

  • Department of Chemistry
  • School of Physical, Chemical & Applied Sciences
  • crrnath.che@pondiuni.edu.in

Academic Activity

Academic Activity Picture1

Academic Activity Picture2

Educational Qualification (UG,PG & Higher Order)

S.No Degree Subject/Title of thesis University/Board Year of Passing
1 PhD Development of New Methods of Resolution of Racemic Diols, Dicarboxylic Acids, Amino Alcohol Derivatives and Their Applications in Asymmetric Organic Synthesis University of Hyderabad 2000
2 M.Sc. Organic Chemistry Madurai Kamaraj University 1993
3 B.Sc. General Chemistry Madurai Kamaraj University 1991

Area of Specializaion

1. Crafting New Chiral Molecules for Asymmetric Catalysis 2. Methodology driven natural product synthesis 3. Drug design and discovery

Awards / Prizes Conferred

S.No Name / Title of the Award Type Name of the Agency conferred the Award Year of the Award Amount for Cash Award
1 Prof. D. K. Banerjee Memorial Lecture Award NATIONAL Department of Organic Chemistry, Indian Institute of Science, Bangalore. 2016 -

Teaching Experience

S.No Designation Department/Centre Institution
1 Assistant Professor Department of Chemistry Pondicherry University
2 Associate Professor Department of Chemistry Pondicherry University

Research Experience

S.No Designation Department/Centre Institution Area of Research
1 Postdoctoral Research Associate H. C. Brown Centre for Borane Research Purdue University Asymmetric synthesis
2 Postdoctoral Research Associate School of Pharmacy University of Connecticut Medicinal Chemistry

Industry Experience

S.No Designation Company/Corporate Nature of Work
1 Research Chemist MAKScientific, LLC, Storrs, Connecticut, USA Research and Development

Contribution towards Innovation

S.No Name of the Work/Contribution Specialization Remarks

Patent Details

S.No Title Status Patent Number Year of Award Type Commercialized Status
1 A process for the preparation of enantiomerically pure isomers of 2,2-dihydroxy-1,1-binaphthyl-3,3-dicarboxylic acid (binol-3,3-dicarboxylic acid) GRANTED 324507 2019 NATIONAL NO

Papers Published in UGC Approved Journals

S.No Title Name of the Authors as per the order in Paper Journal Name Volume, Issue & Page Nos. Year Impact Factor

Papers Published in Peer Reviewed Journals

S.No Title Name of the Authors as per the order in Paper Journal Name Volume, Issue & Page Nos. Year Impact Factor
1 Crystal structure of 4,5,6,7,8,8-hexachloro-2-(3,4-dimethoxyphenethyl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione [+solvent] Manohar, R.; Harikrishna, M.; Harikrishna Etti, S.; Ramanathan, C. R.; Gunasekaran, K. Acta Cryst. E75, 562. 2019 0.35
2 A chiral bicyclic skeleton-tethered bipyridine–Zn(OTf)2 complex as a Lewis acid: enantioselective Friedel–Crafts alkylation of indoles with nitroa Venkatanna, K.; Yeswanth Kumar, S.; Karthick, M.; Padmanaban, R.; Ramanathan, C. R. Org. Biomol. Chem. 17, 4077. 2019 3.562
3 Triflic acid mediated cyclization of N-phenethyl and N-(3-indolylethyl) unsymmetrical succinimides: regio and diastereoselective synthesis of substitu Selvakumar, J.; Mangalaraj, S.; Murali Mohan Achari, K.; Mukund, K.; Ramanathan, C. R. Synthesis 49, 1053. 2017 2.652
4 Brønsted acid-mediated cyclization–dehydrosulfonylation/ reduction sequences: An easy access to pyrazinoisoquinolines and pyridopyrazines Srinivasa Rao, R.; Ramanathan, C. R. Beilstein. J. Org. Chem. 13, 428. 2017 2.697
5 Metal free synthesis of functionalized 1-aryl isoquinolines via iodine mediated oxidative dehydrogenation and ring opening of lactam in isoindoloisoqu Achari, K. M. M.; Karthick., M.; Ramanathan, C. R. J. Chem. Sci. 129, 679. 2017 1.191
6 Conformationally rigid chiral ferrocene derivative: Synthesis, resolution and stereochemical assignment Achari, K. M. M.; Ramanathan, C. R. Tetrahedron: Asymmetry 28, 830. 2017 2.155
7 Desymmetrization of symmetrical triaryl carbinols: Synthesis of 7-aryl fluorenes and new C2-symmetric chiral BIFOL Someshwar, N.; Karthik, M.; Ramanathan, C. R. Synlett 28, 2253. 2017 2.151
8 Catalyst-free allylation of 2-aminophenol–derived aldimines with allyltrichlorosilane under thermal conditions Venkatanna, K.; Ramanathan, C. R. Tetrahedron Lett. 58, 3650. 2017 2.193
9 Controlled, Sequential approach to Synthesize Stereogenic Methanes via in situ Generated Reactive Intermediates Hari krishnan, A.; Gnanasekaran, R.; Ramanathan, C. R. ChemistrySelect 1, 3022. 2016 1.505
10 Synthesis and biological evaluation of isoindoloisoquinolinone, pyroloisoquinolinone and benzoquinazolinone derivatives as PolyADP-Ribose Polymerase-1 Suyavaran, A.; Ramamurthy, CH.; Mareeswaran, R.; Yagna Viswa Shanthi, P.; Selvakumar, J.; Mangalaraj, S.; Suresh Kumar, M.; Ramanathan, C. R.; Thirunavukkarasu, C. Bioorg. Med. Chem. 23, 488. 2015 2.793
11 Cooperative effect of Lewis pair in Friedel-Crafts hydroxyalkylation reaction: A simple and effective route for the synthesis of (±)-carbinoxamine Hari krishnan, A.; Sanjeevi, J.; Ramanathan, C. R. Org. Biomol. Chem. 13, 3633. 2015 3.562
12 Synthesis of condensed tetrahydroisoquinoline class of alkaloids employing TfOH mediated imide carbonyl activation Selvakumar, J.; Srinivasa Rao, R.; Srinivasapriyan, V.; Marutheeswaran, S.; Ramanathan, C. R. Euro. J. Org. Chem. 2175. 2015 3.065
13 Syntheses of fused tetrahydro-β-carboline analogues through imide carbonyl activation using BBr3: Evidence for the involvement of fused cyclic N-acyl Selvakumar, J.; Mangalaraj, S.; Ramanathan, C. R. J. Chem. Sci. 127, 811. 2015 1.191
14 Resolution of (±)-2,2′-dihydroxy-1,1′-binaphthyl-3,3′-dicarboxylic acid using (1R,2R)-trans-cyclohexane-1,2-diamine Someshwar, N.; Ramanathan, C. R. Tetrahedron: Asymmetry 26, 1209. 2015 2.155
15 Conformationally rigid chiral bicyclic skeleton tethered bipyridine N,N′-dioxide as organocatalyst: Asymmetric ring opening of meso-epoxides Gnanamani, E.; Someshwar, N.; Sanjeevi, J.; Ramanathan, C. R. Adv. Synth. Catal. 356, 2219. 2014 5.663
16 Ethyl trans-12-(pyridin-4-yl)-9,10-ethanoanthracene-11-carboxylate Chandrasekar, S.; Prakash Sharma, O.; Srinivasapriyan, V.; SureshKumar, M.; Ramanathan, C. R. Acta Cryst. E70, o512. 2014 0.35
17 Friedel-Crafts hydroxyalkylation through activation of carbonyl group using AlBr3: An easy access to pyridyl aryl / heteroaryl carbinols Harikrishnan, A.; Selvakumar, J.; Gnanamani, E.; Bhattacharya, S.; Ramanathan, C. R. New J. Chem. 37, 563. 2013 3.01
18 Construction of tetrahydro--carboline skeleton via Brønsted acid activation of imide carbonyl group: Syntheses of indole alkaloids (±)-harmicine Mangalaraj, S.; Ramanathan, C. R. RSC Adv. 2, 12665. 2012 3.84
19 Conformationally Rigid Chiral Pyridine N-Oxides as Organocatalyst: Asymmetric Allylation of Aldehydes Gnanamani, E.; Someshwar, N.; Ramanathan, C. R. Adv. Synth. Catal. 354, 2101. 2012 5.663
20 1,7,8,9,10,10-Hexachloro-4-(2-phenylethyl)-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione Manohar, R., Harikrishna, M., Ramanathan, C. R., Suresh Kumar, M., Gunasekaran, K. Acta Cryst. E67, o1708. 2011 0.35
21 1,7,8,9,10,10-Hexachloro-4-(thiophen-2-ylmethyl)-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione Manohar, R., Harikrishna, M., Ramanathan, C. R., Suresh Kumar, M., Gunasekaran, K. Acta Cryst. E67, o2391. 2011 0.35
22 Bronsted acid assisted activation of imide carbonyl group: regioselective synthesis of isoindoloisoquinolinone alkaloid (±)-nuevamine Selvakumar, J.; Ramanathan, C. R. Org. Biomol. Chem. 9, 7643. 2011 3.562
23 An unusual reactivity of BBr3: Accessing tetrahydroisoquinoline derivatives from N-phenethylimides Selvakumar, J.; Makriyannis, A.; Ramanathan, C. R. Org. Biomol. Chem. 8, 4056. 2010 3.562
24 Design, synthesis, resolution, and stereochemical assignment of a conformationally rigid chiral ligand derived from anthracene and a dienophile contai Gnanamani, E.; Ramanathan, C. R. Tetrahedron: Asymmetry 20, 2211. 2009 2.155
25 Drug Discrimination in Methamphetamine-trained Monkeys: Effects of Monoamine Transporter Inhibitors Czoty, P. W.; Ramanathan, C. R.; Mutschler, N. H.; Makriyannis, A.; Bergman, J. J. Pharmacol. Exp. Ther. 311(2), 720. 2004 3.972
26 Asymmetric Dihydroxylation of trans-Stilbene with a New Chiral Ligand prepared using Dihydrocinchonine and the C2-Symmetric Chiral trans-9,10-Dihydro- Periasamy, M.; Ramanathan, C. R.; Kumar, N. S.; Thirumalaikumar, M. J. Chem. Res. 512 2001 0.671
27 New Methods of Resolution and Purification of Racemic and Diastereomeric Amino Alcohol Derivatives Using Boric Acid and Chiral 1,1-bi-2-naphthol Periasamy, M.; Kumar, N. S.; Kumar, S. S.; Dharma Rao, V.; Ramanathan, C. R.; Venkatraman, L. J. Org. Chem. 66, 3828. 2001 4.721
28 A New, Convenient Method of Resolution of Racemic 1,1-bi-2-naphthol Using Boric Acid and R-(+)-*-Methylbenzylamine Periasamy, M.; Venkatraman, L.; Kumar, S. S.; Kumar, N. S.; Ramanathan, C. R. J. Org. Chem., 64, 7643 1999 4.721
29 Resolution of trans-(*)-2-(1-Pyrrolidinyl)cyclohexanol and its Methyl Ether Using Boric Acid and Chiral 1,1-bi-2-naphthol Periasamy, M.; Ramanathan, C. R.; Kumar, N. S. Tetrahedron Asymmetry 10, 2307 1999 2.155
30 Resolution of C2-Symmetric 9,10-Dihydro-9,10-ethanoanthracene-11,12-dicarboxylic acid and 2,3-Diphenylsuccinic acid Using (S)-Proline Ramanathan, C. R.; Periasamy, M. Tetrahedron: Asymmetry 9, 2651. 1998 2.155
31 New Methods of Resolution of Racemic Diols Using (S)-Proline Periasamy, M.; Ramanathan, C. R.; Prasad, A. S. B.; Kanth, J. V. B. Enantiomer 3, 3. 1998 Nil

Papers Published in Conference Proceedings

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Books

S.No Title of the Book Name of the Authors as per the order in Book Publisher Year ISBN No.

Chapters in Books

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Edited Books

S.No Title of the Book Name of the Authors as per the order in Book Publisher Year ISBN No.

Ongoing Projects

S.No Title of the Project Sponsored By Period Sanctioned Amount(Rs. Lakh) Year
1 Conformationally Rigid Chiral Phosphoric Acids for Asymmetric Organic Transformations Science and Engineering Research Board 2020-2023 Rs. 64.69 Lakh 2020

Ongoing Consultancy Works

S.No Title of the Consultancy Work Sponsored By Period Sanctioned Amount(Rs. Lakh) Year

Completed Projects

S.No Title of the Project Sponsored By Period Sanctioned Amount(Rs. Lakh) Year
1 Multifunctional Chiral Molecules for Asymmetric Organic Transformations Department of Science and Technology 2011-2014 Rs. 43.22 Lakh 2011
2 Brønsted Acid Assisted Construction of Biologically Active Isoquinoline Alkaloids Council of Scientific and Industrial Research 2011-2015 Rs. 23.17 Lakh 2011
3 Peptide Based Asymmetric Catalysis – Design and Synthesis of Chiral Ligands for Asymmetric Transformations Department of Science and Technology 2007-2010 Rs. 19.32 Lakh 2007
4 Conformationally Rigid Amino Acids: Synthesis and their Application towards the Designing of New Chiral Ligands Council of Scientific and Industrial Research 2007-2010 Rs. 11.96 Lakh 2007

Completed Consultancy Works

S.No Title of the Consultancy Work Sponsored By Period Sanctioned Amount(Rs. Lakh) Year

Career Guidance Offered to students

S.No Name of the Scheme No. of Students Competitive Examinations/ Career Counseling No. of Students Passed No. of Students Placed

List of capability enhancement such as Soft skill development, Remedial coaching, Language lab,
Bridge courses, Yoga, Meditation, Personal Counselling and Mentoring etc.,

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Research Guidance - PG

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Research Guidance - Ph.D

S.No Student Name Registration Date Registration No. Thesis Title Thesis Submitted Status Thesis Submitted Date Vivavoce Completed Status Date Awarded

Research Guidance - Post Doctoral

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Financial assistance availed to attend conferences / workshops and to pay membership fee
of professional bodies during the year

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E-Lecture Details

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Details of Online Education Conducted

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Invited Talks in Conference/Seminar/Workshop/Training Programme

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Conferences/Seminars Organized

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Workshop Organized

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Administrative Responsibilities in the Government and Quasi Government Agencies

S.No Name of the Position Agency/Organisation Duration Nature of Duties

Affiliation in Academic Bodies/Societies

S.No Name of the Body/Society Nature of Affiliation Year
1 Chemical Research Society of India Life Member 2017

Participation & Extension Activities (Academic/Administraion)

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Participation & Extension Activities (Co-Curricular)

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Collaboration with Institution/Industry

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Institution / Industry
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From Date To Date From Date To Date

Faculty Development Programme Attended (Orientation, Refresher, other Short Term Course during the year)

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Details of Executive Development Prog/Management Development Prog. conducted

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Participation in IMPESS, IMPRINT, SPARC, STARS, LEAP Programme etc and DSF Funding Programme

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Enrolment under ARPIT Programme

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