T. JAYAKUMAR Associate Professor

Profile Picture

  • Department of Ecology & Environmental Sciences
  • School of Life Sciences
  • tjayakumar.ees@pondiuni.edu.in

Academic Activity

Academic Activity Picture1

Academic Activity Picture2

Educational Qualification (UG,PG & Higher Order)

S.No Degree Subject/Title of thesis University/Board Year of Passing
1 PhD Environmental Sciences/Evaluation of the putative antioxidant effect of the mushroom Pleurotus ostreatus in an acute (CCl4- induced) and chronic (age-related) state of oxidative stress in Rattus norvegicus Bharathidasan University, Tiruchirappalli, Tamil N 2008
2 MSc Environmental Sciences Bharathidasan University, Tiruchirappalli, Tamil N 2000
3 BSc Zoology Bharathidasan University, Tiruchirappalli, Tamil N 1998

Area of Specializaion

 Natural products chemistry  Anti-ageing drug analysis  Natural antioxidant therapy  Metallodrugs for Anticancer therapy  Environmental toxicology and molecular phytotherapy, Water and soil quality analysis

Awards / Prizes Conferred

S.No Name / Title of the Award Type Name of the Agency conferred the Award Year of the Award Amount for Cash Award
1 Outstanding Researcher Award INTERNATIONAL Taipei Medical University, Taipei, Taiwan 2020 6000 Taiwan Dollar/
2 Outstanding Researcher Award INTERNATIONAL Taipei Medical University, Taipei, Taiwan 2018 7000 Taiwan Dollar/M
3 Outstanding Researcher Award INTERNATIONAL Taipei Medical University, Taipei, Taiwan 2017 8000 Taiwan Dollar/
4 Outstanding Researcher Award INTERNATIONAL Taipei Medical University, Taipei, Taiwan 2016 10000 Taiwan Dollar/
5 Outstanding Researcher Award INTERNATIONAL Taipei Medical University, Taipei, Taiwan 2015 10000 Taiwan Dollar/
6 Outstanding Researcher Award INTERNATIONAL Taipei Medical University, Taipei, Taiwan 2014 10000 Taiwan Dollar/
7 Outstanding Researcher Award INTERNATIONAL Taipei Medical University, Taipei, Taiwan 2013 10000 Taiwan Dollar/
8 Senior Research Fellowship (SRF) NATIONAL CSIR 2008 24000/month
9 Outstanding academic performance in Post-Graduation STATE Tamil Nadu State Government 2000 6000

Teaching Experience

S.No Designation Department/Centre Institution
1 Teaching Assistant Biotechnology Periyar Maniammai Institute of Science & Technology, Tanjore
2 Researcher-cum Teach Pharmacology Taipei Medical University, Taiwan
3 Associate Professor Department of Ecology & Environmental Sciences Pondicherry University, Puducherry-14

Research Experience

S.No Designation Department/Centre Institution Area of Research
1 Researcher Pharmacology Taipei Medical University, Taiwan  Natural products chemistry  Free radical biology  Anti-ageing drug analysis  Natural antioxidant therapy  Cardiovascular pharmacology  Cancer biology

Industry Experience

S.No Designation Company/Corporate Nature of Work

Contribution towards Innovation

S.No Name of the Work/Contribution Specialization Remarks

Patent Details

S.No Title Status Patent Number Year of Award Type Commercialized Status

Papers Published in UGC Approved Journals

S.No Title Name of the Authors as per the order in Paper Journal Name Volume, Issue & Page Nos. Year Impact Factor
1 Eugenol: A Potential Modulator of Human Platelet Activation and Mouse Mesenteric Vascular Thrombosis via an Innovative cPLA2-NF-κB Signaling Axis. Chang Y, Hsia CW, Chiou KR, Yen TL, Jayakumar T, Sheu JR, Huang WC. Biomedicines. 1689 (12) 1-15. 2024 3.9
2 Eugenol Suppresses Platelet Activation and Mitigates Pulmonary Thromboembolism in Humans and Murine Models. Huang WC, Shu LH, Kuo YJ, Lai KS, Hsia CW, Yen TL, Hsia CH, Jayakumar T, Yang CH, Sheu JR. International Journal of Molecular Science. 25 (4) 2098. 2024 5.6
3 Ginkgetin effectively mitigates collagen and AA- induced platelet activation via PLCγ2 but not cyclic nucleotide-dependent pathway in human. Hsia CW, Shu LH, Lee AW, Tran OT, Yang CH, Yen TL, Huang WC, Hsia CH, Jayakumar T, Chiou KR, Sheu JR. Journal of Cellular and Molecular Medicine 28 (4) 18139. 2024 5.3
4 Ability of Local Clearance of Senescent Cells in Ipsilateral Hemisphere to Mitigate Acute Ischemic Brain Injury in Mice. Lu KJ, Sheu JR, Teng RD, Jayakumar T, Chung CL, Hsieh CY. International Journal of Biological Sciences. 19 (9) 2835-2847. 2023 9.2
5 Overexpressing glyoxalase 1 attenuates acute hyperglycemia-exacerbated neurological deficits of ischemic stroke in mice. Lu KJ, Yang CH, Sheu JR, Chung CL, Jayakumar T, Chen CM, Hsieh CY. Translational Research 261:57-68. 2023 10.17
6 Myricetin as a promising inhibitor of platelet fibrinogen receptor in humans. Chang Y, Hsia CW, Huang WC, Jayakumar T, Hsia CH, Yen TL, Sheu JR, Hou SM. Heliyon. 9 (10) 20286. 2023 4.0
7 Mechanisms of glabridin inhibition of integrin α IIb β 3  inside-out signals and NF-κB activation in human platelets. Huang WC, Jayakumar T, Sheu JR, Hsia CW, Hsia CH, Yen TL, Chang CC. Chinese Medicine. 18 (1) 71. 2023 6.1
8 Garcinol acts as a novel integrin α IIb β 3  inhibitor in human platelets. Hsia CW, Huang WC, Jayakumar T, Hsia CH, Hou SM, Chang CC, Yen TL, Sheu JR. Life Sciences 326:121791. 2023 6.7
9 Activation of Nrf2 by Esculetin Mitigates Inflammatory Responses through Suppression of NF-κB Signaling Cascade in RAW 264.7 Cells Jayakumar T, Huang CJ, Yen TL, Hsia CW, Sheu JR, Saravana Bhavan P, Wei-Chieh Huang WC, Hsieh CY, Hsia, CH. Molecules 27, 5143, 1-14. 2022 4.414
10 Anti-Inflammatory Mechanism of An Alkaloid Rutaecarpine in LTA-Stimulated RAW 264.7 Cells: Pivotal Role on NF-κB and ERK/p38 Signaling Molecules Jayakumar T, Chun-Ming Yang, Ting-Lin Yen, Chia-Yuan Hsu, Joen-Rong Sheu, Chih-Wei Hsia, Manjunath Manubolu, Wei-Chieh Huang, Cheng-Ying Hsieh and Chih-Hsuan Hsia. International Journal of Molecular Sciences 23, 5889. 2022 6.2
11 Phytochemicals of algae, Arthospira platensis (spirulina) Chlorella vulgaris (chlorella) and Azolla pinnata (azolla). Manjula Thangaraj, Bhavan Periyakali Saravana,*, Jayakumar T, Sheu Joen-Rong, Manjunath Manubolu and Kavitha Pathakoti. GSC Biological and Pharmaceutical Sciences. 19(02), 023–043 2022 3.85
12 Glabridin, a Bioactive Flavonoid from Licorice, Effectively Inhibits Platelet Activation in Humans and Mice. Chung CL, Chen JH, Huang WC, Sheu JR, Hsia CW, Jayakumar T, Hsia CH, Chiou KR. Shaw-Min Hou. International Journal of Molecular Sciences 23, 11372, 1-16. 2022 6.2
13 Anti-Inflammatory Mechanism of An Alkaloid Rutaecarpine in LTA-Stimulated RAW 264.7 Cells: Pivotal Role on NF-κB and ERK/p38 Signaling Molecules. Jayakumar T, Yang CM, Yen TL, Hsu CY, Sheu JR, Hsia CW, Manubolu M, Huang WC, Hsieh CY, Hsia CH. International Journal of Molecular Science. 23(11) 5889. 2022 5.6
14 Activation of Nrf2 by Esculetin Mitigates Inflammatory Responses through Suppression of NF-κB Signaling Cascade in RAW 264.7 Cells. Jayakumar T, Huang CJ, Yen TL, Hsia CW, Sheu JR, Bhavan PS, Huang WC, Hsieh CY, Hsia CH. Molecules. 27(16) 5143 2022 4.6
15 Glabridin, a Bioactive Flavonoid from Licorice, Effectively Inhibits Platelet Activation in Humans and Mice. Chung CL, Chen JH, Huang WC, Sheu JR, Hsia CW, Jayakumar T, Hsia CH, Chiou KR, Hou SM. International Journal of Molecular Science. 23(19)11372. 2022 5.6
16 Influence of Garlic (Allium sativum) Clove-Based Selenium Nanoparticles on Status of Nutritional, Biochemical, Enzymological, and Gene Expressions in Satgurunathan T, Bhavan PS, Kalpana R, Jayakumar T, Sheu JR, Manjunath M. Biological Trace Element Research. 201 (4) 2036-2057. 2022 4.081
17 TQ-6, a Novel Ruthenium Derivative Compound, Possesses Potent Free Radical Scavenging Activity in Macrophages and Rats. Hung KW, Chang CC, Jayakumar T, Velusamy M, Hsia CW, Trang NTT, Chou DS, Hsieh CY, Hsia CH. Applied Sciences 11(3), 1008. 2021 2.9
18 Platelet autophagic machinery involved in thrombosis through a novel linkage of AMPK-MTOR to sphingolipid metabolism. Lee TY, Lu WJ, Changou CA, Hsiung YC, Trang NTT, Lee CY, Chang TH, Jayakumar T, Hsieh CY, Yang CH, Chang CC, Chen RJ, Sheu JR, Lin KH. Autophagy 1-18. 2021 16.01
19 Columbianadin dampens in vitro inflammatory actions and inhibits liver injury via inhibition of NF-κB/MAPKs: impacts on OHͦo radicals and HO-1 expre Jayakumar T, Hou SM, Chang CC, Fong TH, Hsia CW, Chen YJ, Huang WC, Saravana Bhavan P, Manubolu M, Sheu JR, Hsia CH. Antioxidant 10(4), 553 2021 7.5
20 Involvement of antioxidant defenses and NF-κB/ERK signaling in anti-inflammatory effects of pterostilbene, a natural analogue of resveratrol. Jayakumar T, Wu MP, Sheu JR, Hsia CW, Saravanabhavan P, Manubolu M, Chung CL, Hsia CH. Applied Sciences 1, 4666, 1-12. 2021 2.9
21 Targeting MAPK/NF-κB Pathways in Anti-Inflammatory Potential of Rutaecarpine: Impact on Src/FAK-Mediated Macrophage Migration. Jayakumar T, Lin KC, Chang CC, Hsia CW, Manubolu M, Huang WC, Sheu JR, Hsia CH. International Journal of Molecular Sciences 23(92), 1-15. 2021 6.02
22 Auraptene, a monoterpene coumarin, inhibits LTA-induced inflammatory mediators via modulating NF-κB/MAPKs signaling pathways. Hsia CH, Jayakumar T #, Lu WJ, Sheu JR, Hsia CW, SaravanaBhavan P, Manubolu M, Huang WC, Chang Y. Evidence-Based Complementary and Alternative Medicine 1-11 2021 2.65
23 Anti-Inflammatory Mechanisms of Novel Synthetic Ruthenium Compounds. Jayakumar T, Sheu JR, Hsia CW, Saravana Bhavan P, Chang CC. Applied Sciences 11, 10092, 1-10. 2021 2.9
24 Effects of Microplastics, Polystyrene, and Polyethylene on Antioxidants, Metabolic Enzymes, HSP-70, and Myostatin Expressions in the Giant River Prawn Monica Jaikumar I, Saravana Bhavan P, Udayasuriyan R, Sheu JR, Jayakumar T, Fong TH. Archives of Environmental Contamination and Toxicology https://doi.org/10.1007/s00244-021-00833-3. 2021 3.1
25 Carbon Dot Nanoparticles Exert Inhibitory Effects on Human Platelets and Reduce Mortality in Mice with Acute Pulmonary Thromboembolism Lee TY, Jayakumar T, Thanasekaran P, Lin KC, Chen HM, Veerakumar P, Sheu JR. Nanomaterials 10(7), 1-15. 2020 5.076
26 Synthetic Ruthenium Complex TQ-6 Potently Recovers Cerebral Ischemic Stroke: Attenuation of Microglia and Platelet Activation. Hsia CH, Jayakumar T, Sheu JR, Hsia CW, Huang WC, Velusamy M, Lien LM. Journal of Clinical Medicine, 94, doi: 10.3390/jcm9040996 2020 4.241
27 Ruthenium derivatives protect LPS-induced liver injury via attenuating inflammatory responses, NF-kB signaling and free radical production: An SAR stu Jayakumar T, Huang HC, Hsia CW, Trang NTT, Fong TH, Khamrang T, Manubolu M, Sheu JR, Hsia CH. Bioorganic Chemistry doi: 10.1016/j.bioorg.2020 2020 5.275
28 Biomass and Lipid Production Potential of an Indian Marine Algal Isolate Tetraselmis straiata BBRR1. Boopathy AB, Jayakumar T, Chinnasamy S, Rajaram MG, Mohan N, Nagaraj S, Rengasamy R, Manubolu M, Sheu JR, Chang CC. Energies 2020. 1-8 2020 3.004
29 Modulation of human platelet activation and in vivo vascular thrombosis by columbianadin: regulation by integrin αIIbβ3 inside-out but not outside- Hou SM, Hsia CW, Tsai CL, Hsia CH, Jayakumar T, Velusamy M, Sheu JR. Journal of Biomedical Science 27, 60 2020 8.410
30 Molecular Targets of Natural Products for Chondroprotection in Destructive Joint Diseases. Jayakumar T, Saravana Bhavan Joen‐Rong Sheu International Journal of Molecular Sciences 21, 4931, 1-21 2020 6.02
31 Novel iridium (III) derived organometallic compound for the inhibition of human platelet activation. Shyu KG, Velusamy M, Hsia CW, Yang CH, Hsia CH, Chou DS, Jayakumar T, Sheu JR, Li JY. International Journal of Molecular Medicine 4177 2019 4.101
32 HDAC6 dysfunction contributes to impaired maturation of adult neurogenesis in vivo: vital role on functional recovery after ischemic stroke. Sheu JR, Hsieh CY, Jayakumar T, Lin CY, Lee HN, Huang SW, Yan CH. Journal of Biomedical Sciences 26:27:1-17. 2019 8.410
33 Mechanisms of TQ-6, a novel ruthenium-derivative compound, against lipopolysaccharide-induced in vitro macrophage activation and liver injury in exper Hsia CH, Velusamy M, Jayakumar T, Chen YJ, Hsia CW, Tsai JH, Teng RD, Sheu JR. Cells 1-16 2019 6.60
34 Protective effects of Ammannia baccifera against CCl4-induced oxidative stress in rats. International Goodla L, Manubolu M, Pathakoti K, Jayakumar T, Fraker M, Tchounwou PB , Poondamalli PR. Journal of Environmental Research and Public Health 168 2019 3.390
35 Esculetin, a coumarin derivative, prevents thrombosis: Inhibitory signaling on PLCγ2–PKC–AKT activation in human platelets. Hsia CW, Lin KC, Lee TY, Hsia CH, Chou DS, Jayakumar T, Velusamy M, Chang CC, Sheu JR. International Journal of Molecular Sciences 20(11), 2731; 2019 2019 6.2
36 Ruthenium complex, TQ-5, protects against LPS-induced macrophage inflammation and acute liver injury in mice via downregulating NF-κB pathways Hou SM, Hsia CH, Velusamy M, Jayakumar T, Hsia CW, Chang CC, Lin KH, Lu YC. International Journal of Molecular Medicine doi: 10.3892/ijmm.2019.4179 2019 4.1
37 Suppression of Human Platelet Activation via Integrin αIIbβ3 Outside-In Independent Signal and Reduction of the Mortality in Pulmonary Thrombosis by Hsia CW, Tsai CL, Sheu JR, Lu WJ, Hsia CH, Velusamy M, Jayakumar T, Li JY. International Journal of Molecular Sciences 20(22), 1-18 2019 6.02
38 A Critical Period for the Development of Schizophrenia-Like Pathology by Aberrant Postnatal Neurogenesis. Sheu JR, Hsieh CY, Jayakumar T, Tseng MF, Lee HN, Huang SW, Manubolu M, Yang CH. Frontiers in Neuroscience 1-18 2019 4.677
39 Possible molecular targets of novel ruthenium complexes in antiplatelet therapy. Jayakumar T, Hsu CY, Khamrang T, Hsia CH, Hsia CW, Manjunath M, Sheu JR. International Journal of Molecular Sciences 19:1-12. 2018 6.2
40 Structure-activity relationship study of newly synthesized iridium-III complexes as potential series for treating thrombotic diseases. Yang CH, Hsia CW, Jayakumar T#, Sheu JR, Hsia CH, Khamrang T, Chen YJ, Manjunath M, Chang Y International Journal of Molecular Sciences 19, 1-12 2018 6.2
41 Analysis of titin in red and white muscles: crucial role on musce contractions using a fish model. Wu MP, Chang NC, Chung CL, Chiu WC, Hsu CC, Chen HM, Sheu JR, Jayakumar T, Chou DS, Fong TH. Biomed Research International 2018 2018 3.411
42 Novel Therapeutic Agent against Platelet Activation In Vitro and Arterial Thrombosis In Vivo by Morin Hydrate. Hsia CW, Wu MP, Velusamy M, Hsia CH, Chou DS, Hsu CY, Jayakumar T, Chung CL, Sheu JR. International Journal of Molecular Sciences 19, 2386, 1-16. 2018 6.2
43 Structure-Antiplatelet Activity Relationships of Novel Ruthenium (II) Complexes: Investigation of Its Molecular Targets. Hsia CH, Jayakumar T#, Sheu JR, Tsao SY, Velusamy M, Hsia CW, Chou DS, Chang CC, Chung CL, Khamrang T, Lin KC. Molecules 22, 1-11 2018 4.411
44 Hinokitiol inhibits migration of A549 lung cancer cells via suppressing MMPs and inducing antioxidant enzymes and apoptosis. Jayakumar T, Liu CH, Wu CY, Lee TY, Manubolu M, Hsieh CY, Yang CH, Sheu JR. International Journal of Molecular Sciences 18(2545), 1-12. 2018 6.2
45 The neuroprotective effects of Tao-Ren-Cheng-Qi Tang against embolic stroke in rats. Hsu LW, Shiao WC, Chang NC, Yu MC, Yen TL, Thomas PA, Jayakumar T*, Sheu JR. Chinese Medicine-UK 12:7, 1-8. 2017 5.455
46 Development of benzimidazole derivatives as novel anti-platelet drugs. Yao WC, Yuan LT, Yang WB, Hsia CH, Huang LT, Lee TY, Sheu JR, Lu WJ, Jayakumar T,* Chen RJ. Current Pharmaceutical Biotechnology 18, 1-12. 2017 3.837
47 Ketamine, a clinically used anesthetic, inhibits vascular smooth muscle cell proliferation via PP2A-activated PI3K/Akt/ERK inhibition Chang Y, Li JY, Jayakumar T, Hung SH, Lee WC, Manjunath M, Sheu JR, Hsu MJ. International Journal of Molecular Sciences 18, 1-12. 2017 6.2
48 Nobiletin, a citrus flavonoid, activates vasodilator-stimulated phosphoprotein in human platelets through non-cyclic nucleotide mechanisms. Jayakumar T, Lin KH, Lu WJ, Lin CY, Geraldine P, Li JY, Sheu JR. International Journal of Molecular Medicine 39,174-182. 2017 4.101
49 A novel indication of platonin, a therapeutic immunomodulating medicine, on neuroprotection against ischemic stroke in mice. Sheu JR, Chen ZC, Jayakumar T, Chou DS, Yen TL, Li HN, Pan SH, Xia ZX, Geraldine P, Yang CH, Hsieh CY. Scientific Report 2017, 1-17. 2017 4.379
50 Structure-activity relationship of three synthesized benzimidazole-based saccharides in human platelets activation. Chang Y, Hsu WH, Yang WB, Jayakumar T, Lee TY, Sheu JR, Lu WJ, Li JY International Journal of Molecular Medicine 40(5), 1520-1528. 2017 4.101
51 A novel ruthenium (II)-derived organometallic compound, TQ-6, potently inhibits platelet aggregation: Ex vivo and in vivo studies. Hsia CH, Velusamy M, Sheu JR, Khamrang T, Jayakumar T, Lu WJ, Lin KH, Chang CC. Scientific Report 7: 9556 2017 4.379
52 Antiplatelet activity of a newly synthesized novel ruthenium (II) complex: potential role for Akt/JNK signaling. Khamrang T, Hung KC, Hsia HC, Hsieh CY, Velusamy M, Jayakumar T*, Sheu, JR International Journal of Molecular Sciences 18, 916 2017 6.2
53 Novel synthetic benzimidazole-derived oligosaccharide, M3BIM, prevents ex vivo platelet aggregation and in vivo thromboembolism. Yen TL, Wu MP, Chung CL, Yang WB, Jayakumar T, Geraldine P, Chou CM, Chang CY, Lu WJ, Sheu JR. Journal of Biomedical Sciences 17, 23(1):26. 2016 8.410
54 Andrographolide stimulates p38 MAPK-Nrf2-HO-1 signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats. Yen TL, Chen RJ, Jayakumar T, Lu WJ, Hsieh CY, Hsu MJ, Yang CH, Chang CC, Lin YK, Lin KH, Sheu JR. Translational Research 170:57-72. 2016 7.012
55 The pharmacodynamics of antiplatelet compounds in thrombosis treatment. Jayakumar T, Yang CH, Geraldine P, Yen TL, Sheu JR. Expert Opinion on Drug Metabolism & Toxicology 1-18. 2016 4.5
56 Astaxanthin, a carotenoid stimulates immune responses via enhancing IFN-γ and IL-2 in primary cultured lymphocytes in vitro and ex vivo. Lin KH, Lin KC, Lu WJ, Thomas PA, Jayakumar T*, Sheu JR. International Journal of Molecular Sciences 17(1), 44 2016 6.02
57 Comparative Decline of the Protein Profiles of Nebulin in Response to Denervation in Skeletal Muscle. Wei JH, Chang NC, Chen SP, Geraldine P, Jayakumar T*, Fong TH. Biochemical and Biophysical Research Communication. 1-8 2015 3.575
58 Antiproliferative activity of hinokitiol, a tropolone derivative, is mediated via the inductions of p-JNK and p-PLCγ1 signaling in PDGF-BB-stimulated Yang PS, Wang MJ, Jayakumar T, Chou DS, Ko CY, Hsu MJ, Hsieh CY. Molecules 20, 8198-8212. 2015 4.411
59 Antrodia camphorata potentiates neuroprotection against cerebral ischemia in rats via down regulation of iNOS/HO-1/Bax and activated caspase-3 and inh Yang PS, Lin PY, Chang CC, Yu MC, Yen TL, Lan CC, Jayakumar T*, Yang CC. Evidence Based Complementary and Alternative Medicine 2014: 1-8. 2015 2.629
60 Hinokitiol, a Tropolone Derivative, Inhibits Mouse Melanoma (B16-F10) Cell Migration and In vivo Tumor Formation Huang CH, Chang CC, Thomas PA, Jayakumar T*, Sheu JR. European Journal of Pharmacology 746: 148-157 2015 4.432
61 Hinokitiol exerts anticancer activity through down regulation of MMPs 9/2 and enhancement of catalase and SOD enzymes: In-vivo augmentation of lung hi Huang CH, Jayakumar T, Fong TH, Lu SH, Thomas PA, Choy CS, Sheu JR Molecules 20, 17720-17734 2015 4.411
62 Andrographolide, a novel NF-κB inhibitor, induces vascular smooth muscle cell apoptosis through a SHP-1-PP2A-p38MAPK-p53 cascade. Chen YY, Hsieh CY, Jayakumar T, Lin KH, Chou DS, Lu WJ, Hsu MJ, Sheu JR. Scientific Report 2014 doi:10.1038/srep05651. 2014 4.379
63 Sanguis draconis, a Dragon’s Blood Resin, Attenuates High Glucose-Induced Oxidative Stress and Vascular Inflammation in Human Umbilical Vein Endoth Chang Y, Chang TC, Chang NC, Huang YK, Choy CS, Jayakumar T*. The Scientific World Journal 1-10. 2014 1.6
64 Protective effect of Actinopteris radiate (Sw.) link. Against CCl4-induced oxidative stress in albino rats. Manjunath M, Lavanya G, Ravilla S, Jayakumar T, Paresh D, Kjell M, Vijayasarathi Reddy, O. Journal of Ethnopharmacology 154, 744-752. 2014 4.36
65 Pleurotus ostreatus, an edible mushroom, enhances glucose 6-phosphate dehydrogenase, ascorbate peroxidase and reduces xanthine dehydrogenase in major Thomas PA, Geraldine P, Jayakumar T*. Pharmaceutical Biology 52(5):646-54. 2014 3.5
66 Brazilin ameliorates high glucose-induced vascular inflammation via inhibiting ROS and CAMs production in human umbilical vein endothelial cells Jayakumar T, Chang CC, Lin SL, Huang YK, Hu CM, Elizebeth AR, Lin SC, Choy CS. Biomed Research International, 2014:403703. 2014 3.411
67 Traditional Chinese medicines and bioactive compounds for the treatment of stroke. Jayakumar T, Elizebeth AR, Yen TL, Sheu JR. Chinese Journal of Integrative Medicine DOI: 10.1007/s11655-014-1782-2. 2014 1.978
68 Anti-cancer effects of CME-1, a novel polysaccharide, purified from the mycelia of Cordyceps sinensis against B16-F10 melanoma cells. Jayakumar T, Chiu CC, Wang SH, Chou DS, Huang YK, Sheu JR. Journal of Cancer Research and Therapeutics 10(1):43-9. 2014 1.805
69 Pharmacology and clinical effect of platonin, a cyanine photosensitizing dye: potential molecular targets. Lee JJ, Chang CF, Sheu JR, Jayakumar T*. Current Pharmaceutical Biotechnology 15 2014 2.837
70 Ex vivo and in vivo studies of CME-1, a novel polysaccharide purified from the mycelia of Cordyceps sinensis that inhibits human platelet activation b Lu WJ, Chang NC, Jayakumar T, Liao JC, Lin MJ, Wang SH, Chou DS, Thomas PA, Sheu JR. Thrombosis Research 134(6):1301-10 2014 3.944
71 Hinokitiol, a natural tropolone derivative, offers neuroprotection from thromboembolic stroke in vivo. Jayakumar T, Hsu WH, Yen TL, Luo JY, Kuo YC, Fong TH, Sheu JR. Evidence Based Complementary and Alternative Medicine 2013:840487. 2013 2.629
72 Cinnamophilin isolated from Cinnamomum philippinense protects against collagen degradation in human chondrocytes Lu YC, Hsiao G, Lin KH, Hsieh MS, Jayakumar T, Wu TS, Sheu JR. Phytotherapy Research 27(6):892-9. 2013 5.878
73 A novel antithrombotic effect of sulforaphane via activation of platelet adenylate cyclase: ex vivo and in vivo studies. Jayakumar T, Chen WF, Lu WJ, Chou DS, Hsiao G, Hsu CY, Sheu JR, Hsieh CY. A Journal of Nutritional Biochemistry 24(6), 1086-95. 2013 6.048
74 Serum p-cresyl sulfate predicts cardiovascular disease and mortality in elderly hemodialysis patients Lin CJ, Chuang CK, Jayakumar T, Liu HL, Pan CF, Wang TJ, Chen HH, Wu CJ. Archives of Medical Science 9(4):662-8 2013 3.318
75 Experimental and clinical pharmacology of Andrographis paniculata and its major bioactive phytoconstituent andrographolide. Jayakumar T, Hsieh CY, Lee JJ, Sheu JR. Evidence Based Complementary and Alternative Medicine 2013:846740. 2013 2.629
76 Inhibitory effect of midazolam on MMP-9, MMP-1 and MMP-13 expression in PMA-stimulated human chondrocytes via recovery of NF-κB signaling. Wang JJ, Huan SK, Hsieh KH, Chou HC, Hsiao G, Jayakumar T*, Sheu JR. Archives of Medical Science 9(2), 332-9. 2013 3.318
77 The role of protein-bound uremic toxins on peripheral artery disease and vascular access failure in patients on hemodialysis. Lin CJ, Pan CF, Liu HL, Chuang CK, Jayakumar T, Wang TJ, Chen HH, Wu CJ. Atherosclerosis, 225 (1) 173-9 2012 5.162
78 In-vitro and in-vivo antioxidant effects of the oyster mushroom Pleurotus ostreatus. Jayakumar T, Thomas PA, Sheu JR, Geraldine P. Food Research International, 44, 851-861. 2011 7.425
79 Chondroprotective role of sesamol by inhibiting MMPs expression via retaining NF-κB signaling in activated SW1353 cells. Lu YC, Jayakumar T, Duann YF, Chou YC, Hsieh CY, Yu SY, Sheu JR, Hsiao G. Journal of Agricultural and Food Chemistry (ACS Journal) 59(9):4969-78 2011 5.279
80 An extract of the Pleurotus ostreatus mushroom bolsters the glutathione redox system in various organs of aged rats Jayakumar T, Thomas PA, Ramesh E, Geraldine P. Journal of Medicinal Food 13(4):771-8.: 2010 2.786
81 An extract of the oyster mushroom, Pleurotus ostreatus, increases catalase gene expression and reduces protein oxidation during aging in rats. Jayakumar T, Thomas PA, Isai M, Geraldine P. Journal of Chinese Integrative Medicine (8):774-80. 2010 doi: 10.3736/jcim20100808.
82 In-vitro antioxidant activities of an ethanolic extract of the oyster mushroom, Pleurotus ostreatus. Jayakumar T, Thomas PA, Geraldine P. Innovative Food Science and Emerging Technologies 10:228-234. 2009 7.10
83 Pleurotus ostreatus, an oyster mushroom, decreases the oxidative stress induced by carbon tetrachloride in rat kidneys, heart and brain Jayakumar T, Sakthivel M, Thomas PA, Geraldine P Chemico-Biological Interaction 176(2-3):108-20 2008 5.168
84 Protective effect of an extract of the oyster mushroom, Pleurotus ostreatus, on antioxidants of major organs of aged rats Jayakumar T, Thomas PA, Geraldine P. Experimental Gerontology 42(3):183-91. 2007 4.253
85 Antioxidant activity of the oyster mushroom, Pleurotus ostreatus, on CCl(4)-induced liver injury in rats Jayakumar T, Ramesh E, Geraldine P. Food and Chemical Toxicology 44(12):1989-96. 2006 5.572
86 Stressor- specific induction of heat shock protein 70 in the fresh water prawn Macrobrachium malcolmsonii (H. Milne Edwards) exposed to the pesticides Selvakumar S, Geraldine P, Shanju S, Jayakumar T. Pesticide Biochemistry and Physiology 82:125-132. 2005 4.966

Papers Published in Non UGC Approved Peer Reviewed Journals

S.No Title Name of the Authors as per the order in Paper Journal Name Volume, Issue & Page Nos. Year Impact Factor
1 Comparison of the potency of pterostilbene with NF-κB inhibitors in platelet activation: Mutual activation by Akt-NF-κB signaling in human platelets Hsia CW, W Huang WC, Yang CH, Hsia CH, Jayakumar T, Saravana Bhavan P, Sheu JR, Chiou KR. Applied Sciences 11,13, 1-13. 2021 2.9
2 Reduction of NF-κB Signals in Platelets and Prolongation of Platelet Plug Formation against High Shear Flow in Whole Blood on Human Subject by Columb Hsia CW, Yang CH, Sheu JR, Hsia CH, Tsai CL, Huang WC, Chen TY, Jayakumar T, Saravana Bhavan P, Chang Y, Chang CC. Applied Sciences 10(20), 7323 2021 2.9
3 TQ-6, a Novel Ruthenium Derivative Compound, Possesses Potent Free Radical Scavenging Activity in Macrophages and Rats. Hung KW, Chang CC, Jayakumar T, Velusamy M, Hsia CW, Trang NTT, Chou DS, Hsieh CY, Hsia CH. Applied Sciences 11(3), 1008. 2021 2.9
4 Anti-neuroinflammatory Effect of Newly Synthesized Iridium Metal Complexes in LPS-induced Microglia Cells. Chen YJ, Yuan KC, Jayakumar T, Hsia CH, Hsia CW, Velusamy M, Chou DS, Hou SM. International Journal of Pharmacology -11, 2019 0,8
5 Biofuel and biochemical analysis of Amphora coffeaeformis RR03, a novel marine diatom, cultivated in an open raceway pond. Rajaram MG, Nagaraj S, Manjunath M, Baskara Boopathy A, Kurinjimalar C, Rengasamy R, Jayakumar T, Sheu JR, Li JY. Energies 11, 1341, 1-13. 2018 3.004
6 Inhibitory effect of PDGF-BB and serum-stimulated responses in vascular smooth muscle cell proliferation by hinokitiol via up-regulation of p21 and p5 Li JY, Liu CP, Shiao WC, Jayakumar T, Li YS, Chang NC, Huang SY, Hsieh CY. Archieves of Medical Science. 14(3):579-587. 2018 3.318
7 Possible molecular targets of novel ruthenium complexes in antiplatelet therapy. Jayakumar T, Hsu CY, Khamrang T, Hsia CH, Hsia CW, Manjunath M, Sheu JR. International Journal of Molecular Sciences 19:1-12. 2018 6.02
8 Multi-targeting andrographolide, a Novel NF-κB Inhibitor, as potential therapeutic agent for stroke. Yang CH, Yen TL, Hsu CY, Thomas PA, Sheu JR, Jayakumar T*. International Journal of Molecular Sciences 18:1-14. 2017 6.02
9 Mechanisms of free radical generation in platelets and primary hepatocytes: A novel electron spin resonance study Wang CL, Tsao JT, Jayakumar T, Sheu JR, Chou DS. Molecular Medicine Report 17 (1), 2061-2069 2017 2.952
10 New therapeutic agent against arterial thrombosis: An iridium(III)-derived organometallic compound Hsia CW, Velusamy M, Tsao JT, Hsia CH, Chou DS, Jayakumar T, Lee LW, Li JY, Sheu JR. International Journal of Molecular Sciences 18, 1-16. 2017 6.02
11 Inhibitory Mechanisms of CME-1, a Novel Polysaccharide from the Mycelia of Cordyceps sinensis, in Platelet Activation Chang Y, Hsu WH, Lu WJ, Jayakumar T, Liao JC, Lin MJ, Wang SH, Geraldine P, Lin KH, Sheu JR. Current Pharmaceutical Biotechnology 16(5):451-61. 2015 2.837
12 Inhibitory signaling of 17β-estradiol in platelet activation: the pivotal role of cyclic AMP-mediated nitric oxide synthase activation. Wu GJ, Lee JJ, Chou DS, Jayakumar T, Hsiao G, Chen WF, Sheu JR. European Journal of Pharmacology 649(1-3):140-9. 2015 4.432
13 Potential Advantages of a Combination of Traditional Chinese Medicine, Tao-Hong-Si-Wu-Tang and tissue-Plasminogen Activator for Alleviating Middle Cer Yen TL, Lin KH, Chang CC, Jayakumar T, Fong SH, Sheu JR. Chinese Journal of Integrative Medicine DOI:10.1007/s11655-014-1847-x 2014 1.978
14 Andrographolide, a novel NF-kB inhibitor, inhibits vascular smooth muscle cell proliferation and cerebral endothelial cell inflammation. Chang CC, Duann YF, Yen TL, Chen YY, Jayakumar T, Ong ET, Sheu JR. Acta Cardiologica Sinica 30; 1-8. 2014 2.672
15 Hinokitiol, a natural tropolone derivative, offers neuroprotection from thromboembolic stroke in vivo. Jayakumar T, Hsu WH, Yen TL, Luo JY, Kuo YC, Fong TH, Sheu JR. Evidence Based Complementary and Alternative Medicine 2013:840487 2013 2.629
16 Indoxyl sulfate predicts cardiovascular disease and renal function deterioration in advanced chronic kidney disease. Lin CJ, Liu HL, Pan CF, Chuang CK, Jayakumar T, Wang TJ, Chen HH, Wu CJ. Archives of Medical Research 43(6):451-6 2012 2.235
17 Andrographolide enhances nuclear factor-kappaB subunit p65 Ser536 dephosphorylation through activation of protein phosphatase 2A in vascular smooth mu Hsieh CY, Hsu MJ, Hsiao G, Wang YH, Huang CW, Chen SW, Jayakumar T, Chiu PT, Chiu YH, Sheu JR. Journal of Biological Chemistry 286(8):5942-55. 2011 5.486
18 A novel role of andrographolide, an NF-kappa B inhibitor, on inhibition of platelet activation: the pivotal mechanisms of endothelial nitric oxide syn Lu WJ, Lee JJ, Chou DS, Jayakumar T, Fong TH, Hsiao G, Sheu JR. Journal of Nutritional Biochemistry 89(12):1261-73 2011 6.048
19 Inhibition of vascular smooth muscle cell proliferation by the vitamin E derivative pentamethylhydroxychromane in an in vitro and in vivo study: pivot Hsieh CY, Liu CL, Hsu MJ, Jayakumar T, Chou DS, Wang YH, Hsiao G, Sheu JR. Free Radical Biology and Medicine 49(5):881-93 2010 7.376
20 Cyclic nucleotides and mitogen-activated protein kinases: regulation of simvastatin in platelet activation Lee YM, Chen WF, Chou DS, Jayakumar T, Hou SY, Lee JJ, Hsiao G, Sheu JR. Journal of Biomedical Science 17, 45 2010 8.923
21 Arsenic trioxide-mediated antiplatelet activity: pivotal role of the phospholipase C gamma 2-protein kinase C-p38 MAPK cascade. Lin KH, Chang YF, Fan CY, Jayakumar T, Lee JJ, Chou DS, Hsiao G, Sheu JR. Translational Research 155(2):97-108. 2010 10.171
22 Potent antiplatelet activity of sesamol in an in vitro and in vivo model: pivotal roles of cyclic AMP and p38 mitogen-activated protein kinase. Chang CC, Lu WJ, Chiang CW, Jayakumar T, Ong ET, Hsiao G, Fong TH, Chou DS, Sheu JR Journal of Nutritional Biochemistry 21(12):1214-21 2010 6.048
23 Comparison of the relative activities of inducing platelet apoptosis stimulated by various platelet-activating agents Lin KH, Chang HC, Lu WJ, Jayakumar T, Chou HC, Fong TH, Hsiao G, Sheu JR. Platelets 20(8):575-81. 2009 3.862
24 Green tea catechins, alleviate hepatic lipidemic-oxidative injury in Wistar rats fed an atherogenic diet. Ramesh E, Jayakumar T, Elanchezhian R, Sakthivel M, Geraldine P, Thomas PA. Chemico- Biological Interaction 80(1):10-9. 2009 5.168
25 Epigallocatechin gallate improves serum lipid profile and erythrocyte and cardiac tissue antioxidant parameters in Wistar rats fed an atherogenic diet Ramesh E, Elanchezhian R, Sakthivel M, Jayakumar T, Senthil Kumar RS, Geraldine P, Thomas PA. Fundamental and Clinical Pharmacology 22(3):275-84 2008 2.748

Papers Published in Conference Proceedings

S.No Title Name of the Authors as per the order in Paper Details of Conference Publication Page Nos. Year

Books

S.No Title of the Book Name of the Authors as per the order in Book Publisher Year ISBN No.

Chapters in Books

S.No Title of the Chapters Name of the Authors Title of the Book Publisher Year ISBN No.
1 Nanotechnology-Based Detection and Remediation of Mycotoxins for Food and Agriculture Applications. 1. Manubolu M, Lavanya G, Ludsin SA, Jayakumar T, Fraker M, Kavitha P Nanosensors for Environment, Food and Agriculture Springer Nature 2021 DOI: 10.1007/978-3-030-63245-8_9

Edited Books

S.No Title of the Book Name of the Authors as per the order in Book Publisher Year ISBN No.

Ongoing Projects

S.No Title of the Project Sponsored By Period Sanctioned Amount(Rs. Lakh) Year
1 Molecular Mechanism of Newly Synthesized Ruthenium (II) Metal Complexes in the Treatment of Lung Adenocarcinoma: Innovative Therapeutic Advantages. SERB-CRG 2024-2027 43 2024

Ongoing Consultancy Works

S.No Title of the Consultancy Work Sponsored By Period Sanctioned Amount(Rs. Lakh) Year
1 Biodiversity Study in Cluster Quarry located in Theni District, Tamil Nadu Quarry Proponents [Directed by State Environmental Impact Assessment Authority (SIEA), Tamil Nadu]. 2024 Feb. to 2024 August 6 2024
2 Biodiversity Study in Cluster Quarry located in Karur District, Tamil Nadu Quarry Proponents [Directed by State Environmental Impact Assessment Authority (SIEA), Tamil Nadu]. 2024 July to 2024 Novembe 3.5 2024

Completed Projects

S.No Title of the Project Sponsored By Period Sanctioned Amount(Rs. Lakh) Year

Completed Consultancy Works

S.No Title of the Consultancy Work Sponsored By Period Sanctioned Amount(Rs. Lakh) Year

Career Guidance Offered to students

S.No Name of the Scheme No. of Students Competitive Examinations/ Career Counseling No. of Students Passed No. of Students Placed

List of capability enhancement such as Soft skill development, Remedial coaching, Language lab,
Bridge courses, Yoga, Meditation, Personal Counselling and Mentoring etc.,

S.No Name of the Programme/Scheme Date of Implementation No. of Students Enrolled Agencies Involved

Research Guidance - PG

S.No Year Degree No. of Students Awarded Department/Centre
1 2024 M.SC 5 Department of Ecology & Environmental Sciences
2 2023 M.SC 3 Department of Ecology & Environmental Sciences
3 2022 M.SC 1 Department of Ecology & Environmental Sciences

Research Guidance - Ph.D

S.No Student Name Registration Date Registration No. Thesis Title Thesis Submitted Status Thesis Submitted Date Vivavoce Completed Status Date Awarded
1 Mohammad Maaz 15-02-2023 2200111001 Chondroprotective roles of chosen plant extracts in Cadmium-induced In-vivo Osteoarthritis (OA) and In-vitro Chondrocytes degradation. NO NO
2 Pushpa Latha Manda 03-11-2023 2300111006 Therapeutic effect of Medicinal plant against heavy metal toxicity on fresh water prawn Macrobrachium Rosenbergii : impact on molecular markers. NO NO
3 Kiruthika A 03-11-2023 2300111004 Functionalized Nano Encapsulated Phytodrug in the Treatment of Lung Carcinoma. NO NO
4 Abinesh Muthaiyan 07-11-2023 2300111001 Life History, Ecology and Conservation of Madras Hedgehog (Paraechinus nudiventris) in South India. NO NO
5 Gajal Gupta 25-03-2024 2300111016 Study the Impact of Urbanization on Common Myna (Acridotheres tristis): Putative Role of Adaptive Ecology and Genomic Expression in their Survival NO NO

Research Guidance - Post Doctoral

S.No Scholar Name Designation Funding Agency Fellowship Title Year of Joining Year of Completion

Financial assistance availed to attend conferences / workshops and to pay membership fee
of professional bodies during the year

S.No Conference/ workshop attended for which financial support provided Professional body for which membership fee is provided Amount of Support Place From Date To Date Year

E-Lecture Details

S.No E-Lecture Title Development of e-content/e-learning/delivering Member of Editorial Bodies Reviewer/Referee of
Content/Module Title Institution/Platform Year Weblink

Details of Online Education Conducted

S.No Nature of Online Course No. of Sessions Target Group Date

Invited Talks in Conference/Seminar/Workshop/Training Programme

S.No Title of the Paper Conferences/Seminar/Workshop/Training Programme Organized by Whether International / National / State / Regional / College or University Level From To Year
1 Prevention of Cardiovascular Diseases using Natural Products. Invited Talk 2023 Bharadhiar University, Coimbatore, Tamil Nadu University level 27-07-2023 27-07-2023 2023

Conferences/Seminars Organized

S.No Title of the Programme Sponsors Venue & Duration Whether International / National / State / Regional / College or University Level From To Year
1 IAAP Conference UGC - HRDC Pondicherry University International 02-02-2024 04-02-2024 2024
2 XLVI Indian Social Science Congress Indian Social Science Academy & Bharathidasan University. Tiruchirapalli, Tamil Nadu. National 27-01-2023 31-01-2023 2023
3 Environmental Degradation and Pandemic Department of Geography, Govt. Arts College, Salem, Tamil nadu Online International 26-06-2020 26-06-2020 2020

Workshop Organized

S.No Title of the Programme Sponsors Venue & Duration Whether International / National / State / Regional / College or University Level From To Year

Administrative Responsibilities in the Government and Quasi Government Agencies

S.No Name of the Position Agency/Organisation Duration Nature of Duties
1 Member PPCC - Puducherry Pollution Control Committee 2024 Examining proposals for No increase in pollution Load certificate and Identification of Materials generated from Industrial Processes as Wastes.
2 External Examinar Bharathiar University, Tamil Nadu, India. 2023 Ph.D Viva-voce Examination
3 Member in Flying Squad II Pondicherry University 2023-Jan / Feb Inspection in the affiliated colleges and submit a compliance report.
4 Member in Flying Squad II Pondicherry University 2023- July / Aug Inspection in the affiliated colleges and submit a compliance report

Affiliation in Academic Bodies/Societies

S.No Name of the Body/Society Nature of Affiliation Year

Participation & Extension Activities (Academic/Administraion)

S.No Name of the Position (Head, Dean, Co-ordinator, Director, etc.,) Duration Nature of Dutites

Participation & Extension Activities (Co-Curricular)

S.No Name of the Position (NSS, NCC, Warden etc.,) Duration Nature of Dutites

Collaboration with Institution/Industry

S.No Collaborator Name Designation Institution/Industry Type Nature of Collaboration Period of Collaboration Visits to Collaborating
Institution / Industry		 Details of Collaborative Research/Teaching
From Date To Date From Date To Date

Faculty Development Programme Attended (Orientation, Refresher, other Short Term Course during the year)

S.No Title of the FDP Organiser Venue Duration From Date To Date Year

Details of Executive Development Prog/Management Development Prog. conducted

S.No Name of the Programme No. of Participants Venue Duration From Date To Date Year Revenue Generated

Participation in IMPESS, IMPRINT, SPARC, STARS, LEAP Programme etc and DSF Funding Programme

S.No IMPRESS/IMPRINT/SPARC/STARS/LEAP/Others Place From Date To Date Year

Enrolment under ARPIT Programme

S.No Name of the Programme Period of the Programme
From Date To Date