T. JAYAKUMAR Associate Professor

Profile Picture

  • Department of Ecology & Environmental Sciences
  • School of Life Sciences
  • tjayakumar.ees@pondiuni.edu.in

Academic Activity

Academic Activity Picture1

Academic Activity Picture2

Educational Qualification (UG,PG & Higher Order)

S.No Degree Subject/Title of thesis University/Board Year of Passing
1 PhD Environmental Sciences/Evaluation of the putative antioxidant effect of the mushroom Pleurotus ostreatus in an acute (CCl4- induced) and chronic (age-related) state of oxidative stress in Rattus norvegicus Bharathidasan University, Tiruchirappalli, Tamil N 2008
2 MSc Environmental Sciences Bharathidasan University, Tiruchirappalli, Tamil N 2000
3 BSc Zoology Bharathidasan University, Tiruchirappalli, Tamil N 1998

Area of Specializaion

 Stress biology  Natural products chemistry  Anti-ageing drug analysis  Natural antioxidant therapy  Cardiovascular pharmacology  Environmental toxicology and molecular phytotherapy, Water and soil quality analysis

Awards / Prizes Conferred

S.No Name / Title of the Award Type Name of the Agency conferred the Award Year of the Award Amount for Cash Award
1 Outstanding Researcher Award INTERNATIONAL Taipei Medical University, Taipei, Taiwan 2020 6000 Taiwan Dollar/
2 Outstanding Researcher Award INTERNATIONAL Taipei Medical University, Taipei, Taiwan 2018 7000 Taiwan Dollar/M
3 Outstanding Researcher Award INTERNATIONAL Taipei Medical University, Taipei, Taiwan 2017 8000 Taiwan Dollar/
4 Outstanding Researcher Award INTERNATIONAL Taipei Medical University, Taipei, Taiwan 2016 10000 Taiwan Dollar/
5 Outstanding Researcher Award INTERNATIONAL Taipei Medical University, Taipei, Taiwan 2015 10000 Taiwan Dollar/
6 Outstanding Researcher Award INTERNATIONAL Taipei Medical University, Taipei, Taiwan 2014 10000 Taiwan Dollar/
7 Outstanding Researcher Award INTERNATIONAL Taipei Medical University, Taipei, Taiwan 2013 10000 Taiwan Dollar/
8 Senior Research Fellowship (SRF) NATIONAL CSIR 2008 24000/month
9 Outstanding academic performance in Post-Graduation STATE Tamil Nadu State Government 2000 6000

Teaching Experience

S.No Designation Department/Centre Institution
1 Teaching Assistant Biotechnology Periyar Maniammai Institute of Science & Technology, Tanjore
2 Researcher-cum Teach Pharmacology Taipei Medical University, Taiwan
3 Associate Professor Department of Ecology & Environmental Sciences Pondicherry University, Puducherry-14

Research Experience

S.No Designation Department/Centre Institution Area of Research
1 Researcher Pharmacology Taipei Medical University, Taiwan  Natural products chemistry  Free radical biology  Anti-ageing drug analysis  Natural antioxidant therapy  Cardiovascular pharmacology  Cancer biology

Industry Experience

S.No Designation Company/Corporate Nature of Work

Contribution towards Innovation

S.No Name of the Work/Contribution Specialization Remarks

Patent Details

S.No Title Status Patent Number Year of Award Type Commercialized Status

Papers Published in UGC Approved Journals

S.No Title Name of the Authors as per the order in Paper Journal Name Volume, Issue & Page Nos. Year Impact Factor
1 Phytochemicals of algae, Arthospira platensis (spirulina) Chlorella vulgaris (chlorella) and Azolla pinnata (azolla). Manjula Thangaraj, Bhavan Periyakali Saravana,*, Jayakumar T, Sheu Joen-Rong, Manjunath Manubolu and Kavitha Pathakoti. GSC Biological and Pharmaceutical Sciences. 19(02), 023–043 2022 3.85
2 Anti-Inflammatory Mechanism of An Alkaloid Rutaecarpine in LTA-Stimulated RAW 264.7 Cells: Pivotal Role on NF-κB and ERK/p38 Signaling Molecules Jayakumar T, Chun-Ming Yang, Ting-Lin Yen, Chia-Yuan Hsu, Joen-Rong Sheu, Chih-Wei Hsia, Manjunath Manubolu, Wei-Chieh Huang, Cheng-Ying Hsieh and Chih-Hsuan Hsia. International Journal of Molecular Sciences 23, 5889. 2022 6.2
3 Activation of Nrf2 by Esculetin Mitigates Inflammatory Responses through Suppression of NF-κB Signaling Cascade in RAW 264.7 Cells Jayakumar T, Huang CJ, Yen TL, Hsia CW, Sheu JR, Saravana Bhavan P, Wei-Chieh Huang WC, Hsieh CY, Hsia, CH. Molecules 27, 5143, 1-14. 2022 4.414
4 Glabridin, a Bioactive Flavonoid from Licorice, Effectively Inhibits Platelet Activation in Humans and Mice. Chung CL, Chen JH, Huang WC, Sheu JR, Hsia CW, Jayakumar T, Hsia CH, Chiou KR. Shaw-Min Hou. International Journal of Molecular Sciences 23, 11372, 1-16. 2022 6.2
5 Auraptene, a monoterpene coumarin, inhibits LTA-induced inflammatory mediators via modulating NF-κB/MAPKs signaling pathways. Hsia CH, Jayakumar T #, Lu WJ, Sheu JR, Hsia CW, SaravanaBhavan P, Manubolu M, Huang WC, Chang Y. Evidence-Based Complementary and Alternative Medicine 1-11 2021 2.65
6 Anti-Inflammatory Mechanisms of Novel Synthetic Ruthenium Compounds. Jayakumar T, Sheu JR, Hsia CW, Saravana Bhavan P, Chang CC. Applied Sciences 11, 10092, 1-10. 2021 2.9
7 Targeting MAPK/NF-κB Pathways in Anti-Inflammatory Potential of Rutaecarpine: Impact on Src/FAK-Mediated Macrophage Migration. Jayakumar T, Lin KC, Chang CC, Hsia CW, Manubolu M, Huang WC, Sheu JR, Hsia CH. International Journal of Molecular Sciences 23(92), 1-15. 2021 6.02
8 TQ-6, a Novel Ruthenium Derivative Compound, Possesses Potent Free Radical Scavenging Activity in Macrophages and Rats. Hung KW, Chang CC, Jayakumar T, Velusamy M, Hsia CW, Trang NTT, Chou DS, Hsieh CY, Hsia CH. Applied Sciences 11(3), 1008. 2021 2.9
9 Involvement of antioxidant defenses and NF-κB/ERK signaling in anti-inflammatory effects of pterostilbene, a natural analogue of resveratrol. Jayakumar T, Wu MP, Sheu JR, Hsia CW, Saravanabhavan P, Manubolu M, Chung CL, Hsia CH. Applied Sciences 1, 4666, 1-12. 2021 2.9
10 Columbianadin dampens in vitro inflammatory actions and inhibits liver injury via inhibition of NF-κB/MAPKs: impacts on OHͦo radicals and HO-1 expre Jayakumar T, Hou SM, Chang CC, Fong TH, Hsia CW, Chen YJ, Huang WC, Saravana Bhavan P, Manubolu M, Sheu JR, Hsia CH. Antioxidant 10(4), 553 2021 7.5
11 Platelet autophagic machinery involved in thrombosis through a novel linkage of AMPK-MTOR to sphingolipid metabolism. Lee TY, Lu WJ, Changou CA, Hsiung YC, Trang NTT, Lee CY, Chang TH, Jayakumar T, Hsieh CY, Yang CH, Chang CC, Chen RJ, Sheu JR, Lin KH. Autophagy 1-18. 2021 16.01
12 Effects of Microplastics, Polystyrene, and Polyethylene on Antioxidants, Metabolic Enzymes, HSP-70, and Myostatin Expressions in the Giant River Prawn Monica Jaikumar I, Saravana Bhavan P, Udayasuriyan R, Sheu JR, Jayakumar T, Fong TH. Archives of Environmental Contamination and Toxicology https://doi.org/10.1007/s00244-021-00833-3. 2021 3.1
13 Biomass and Lipid Production Potential of an Indian Marine Algal Isolate Tetraselmis straiata BBRR1. Boopathy AB, Jayakumar T, Chinnasamy S, Rajaram MG, Mohan N, Nagaraj S, Rengasamy R, Manubolu M, Sheu JR, Chang CC. Energies 2020. 1-8 2020 3.004
14 Modulation of human platelet activation and in vivo vascular thrombosis by columbianadin: regulation by integrin αIIbβ3 inside-out but not outside- Hou SM, Hsia CW, Tsai CL, Hsia CH, Jayakumar T, Velusamy M, Sheu JR. Journal of Biomedical Science 27, 60 2020 8.410
15 Molecular Targets of Natural Products for Chondroprotection in Destructive Joint Diseases. Jayakumar T, Saravana Bhavan Joen‐Rong Sheu International Journal of Molecular Sciences 21, 4931, 1-21 2020 6.02
16 Synthetic Ruthenium Complex TQ-6 Potently Recovers Cerebral Ischemic Stroke: Attenuation of Microglia and Platelet Activation. Hsia CH, Jayakumar T, Sheu JR, Hsia CW, Huang WC, Velusamy M, Lien LM. Journal of Clinical Medicine, 94, doi: 10.3390/jcm9040996 2020 4.241
17 Ruthenium derivatives protect LPS-induced liver injury via attenuating inflammatory responses, NF-kB signaling and free radical production: An SAR stu Jayakumar T, Huang HC, Hsia CW, Trang NTT, Fong TH, Khamrang T, Manubolu M, Sheu JR, Hsia CH. Bioorganic Chemistry doi: 10.1016/j.bioorg.2020 2020 5.275
18 Carbon Dot Nanoparticles Exert Inhibitory Effects on Human Platelets and Reduce Mortality in Mice with Acute Pulmonary Thromboembolism Lee TY, Jayakumar T, Thanasekaran P, Lin KC, Chen HM, Veerakumar P, Sheu JR. Nanomaterials 10(7), 1-15. 2020 5.076
19 Esculetin, a coumarin derivative, prevents thrombosis: Inhibitory signaling on PLCγ2–PKC–AKT activation in human platelets. Hsia CW, Lin KC, Lee TY, Hsia CH, Chou DS, Jayakumar T, Velusamy M, Chang CC, Sheu JR. International Journal of Molecular Sciences 20(11), 2731; 2019 2019 6.2
20 A Critical Period for the Development of Schizophrenia-Like Pathology by Aberrant Postnatal Neurogenesis. Sheu JR, Hsieh CY, Jayakumar T, Tseng MF, Lee HN, Huang SW, Manubolu M, Yang CH. Frontiers in Neuroscience 1-18 2019 4.677
21 Suppression of Human Platelet Activation via Integrin αIIbβ3 Outside-In Independent Signal and Reduction of the Mortality in Pulmonary Thrombosis by Hsia CW, Tsai CL, Sheu JR, Lu WJ, Hsia CH, Velusamy M, Jayakumar T, Li JY. International Journal of Molecular Sciences 20(22), 1-18 2019 6.02
22 Ruthenium complex, TQ-5, protects against LPS-induced macrophage inflammation and acute liver injury in mice via downregulating NF-κB pathways Hou SM, Hsia CH, Velusamy M, Jayakumar T, Hsia CW, Chang CC, Lin KH, Lu YC. International Journal of Molecular Medicine doi: 10.3892/ijmm.2019.4179 2019 4.1
23 Protective effects of Ammannia baccifera against CCl4-induced oxidative stress in rats. International Goodla L, Manubolu M, Pathakoti K, Jayakumar T, Fraker M, Tchounwou PB , Poondamalli PR. Journal of Environmental Research and Public Health 168 2019 3.390
24 Novel iridium (III) derived organometallic compound for the inhibition of human platelet activation. Shyu KG, Velusamy M, Hsia CW, Yang CH, Hsia CH, Chou DS, Jayakumar T, Sheu JR, Li JY. International Journal of Molecular Medicine 4177 2019 4.101
25 Mechanisms of TQ-6, a novel ruthenium-derivative compound, against lipopolysaccharide-induced in vitro macrophage activation and liver injury in exper Hsia CH, Velusamy M, Jayakumar T, Chen YJ, Hsia CW, Tsai JH, Teng RD, Sheu JR. Cells 1-16 2019 6.60
26 HDAC6 dysfunction contributes to impaired maturation of adult neurogenesis in vivo: vital role on functional recovery after ischemic stroke. Sheu JR, Hsieh CY, Jayakumar T, Lin CY, Lee HN, Huang SW, Yan CH. Journal of Biomedical Sciences, 26:27:1-17. 2019 8.410
27 Possible molecular targets of novel ruthenium complexes in antiplatelet therapy. Jayakumar T, Hsu CY, Khamrang T, Hsia CH, Hsia CW, Manjunath M, Sheu JR. International Journal of Molecular Sciences 19:1-12. 2018 6.2
28 Analysis of titin in red and white muscles: crucial role on musce contractions using a fish model. Wu MP, Chang NC, Chung CL, Chiu WC, Hsu CC, Chen HM, Sheu JR, Jayakumar T, Chou DS, Fong TH. Biomed Research International, 2018 2018 3.411
29 Structure-activity relationship study of newly synthesized iridium-III complexes as potential series for treating thrombotic diseases. Yang CH, Hsia CW, Jayakumar T#, Sheu JR, Hsia CH, Khamrang T, Chen YJ, Manjunath M, Chang Y International Journal of Molecular Sciences 19, 1-12 2018 6.2
30 Novel Therapeutic Agent against Platelet Activation In Vitro and Arterial Thrombosis In Vivo by Morin Hydrate. Hsia CW, Wu MP, Velusamy M, Hsia CH, Chou DS, Hsu CY, Jayakumar T, Chung CL, Sheu JR. International Journal of Molecular Sciences 19, 2386, 1-16. 2018 6.2
31 Hinokitiol inhibits migration of A549 lung cancer cells via suppressing MMPs and inducing antioxidant enzymes and apoptosis. Jayakumar T, Liu CH, Wu CY, Lee TY, Manubolu M, Hsieh CY, Yang CH, Sheu JR. International Journal of Molecular Sciences 18(2545), 1-12. 2018 6.2
32 Structure-Antiplatelet Activity Relationships of Novel Ruthenium (II) Complexes: Investigation of Its Molecular Targets. Hsia CH, Jayakumar T#, Sheu JR, Tsao SY, Velusamy M, Hsia CW, Chou DS, Chang CC, Chung CL, Khamrang T, Lin KC. Molecules 22, 1-11 2018 4.411
33 Ketamine, a clinically used anesthetic, inhibits vascular smooth muscle cell proliferation via PP2A-activated PI3K/Akt/ERK inhibition Chang Y, Li JY, Jayakumar T, Hung SH, Lee WC, Manjunath M, Sheu JR, Hsu MJ. International Journal of Molecular Sciences 18, 1-12. 2017 6.2
34 The neuroprotective effects of Tao-Ren-Cheng-Qi Tang against embolic stroke in rats. Hsu LW, Shiao WC, Chang NC, Yu MC, Yen TL, Thomas PA, Jayakumar T*, Sheu JR. Chinese Medicine-UK 12:7, 1-8. 2017 5.455
35 A novel ruthenium (II)-derived organometallic compound, TQ-6, potently inhibits platelet aggregation: Ex vivo and in vivo studies. Hsia CH, Velusamy M, Sheu JR, Khamrang T, Jayakumar T, Lu WJ, Lin KH, Chang CC. Scientific Report 7: 9556 2017 4.379
36 Antiplatelet activity of a newly synthesized novel ruthenium (II) complex: potential role for Akt/JNK signaling. Khamrang T, Hung KC, Hsia HC, Hsieh CY, Velusamy M, Jayakumar T*, Sheu, JR International Journal of Molecular Sciences 18, 916 2017 6.2
37 Nobiletin, a citrus flavonoid, activates vasodilator-stimulated phosphoprotein in human platelets through non-cyclic nucleotide mechanisms. Jayakumar T, Lin KH, Lu WJ, Lin CY, Geraldine P, Li JY, Sheu JR. . International Journal of Molecular Medicine 39,174-182. 2017 4.101
38 Development of benzimidazole derivatives as novel anti-platelet drugs. Yao WC, Yuan LT, Yang WB, Hsia CH, Huang LT, Lee TY, Sheu JR, Lu WJ, Jayakumar T,* Chen RJ. Current Pharmaceutical Biotechnology 18, 1-12. 2017 3.837
39 Structure-activity relationship of three synthesized benzimidazole-based saccharides in human platelets activation. Chang Y, Hsu WH, Yang WB, Jayakumar T, Lee TY, Sheu JR, Lu WJ, Li JY International Journal of Molecular Medicine 40(5), 1520-1528. 2017 4.101
40 A novel indication of platonin, a therapeutic immunomodulating medicine, on neuroprotection against ischemic stroke in mice. Sheu JR, Chen ZC, Jayakumar T, Chou DS, Yen TL, Li HN, Pan SH, Xia ZX, Geraldine P, Yang CH, Hsieh CY. Scientific Report 2017, 1-17. 2017 4.379
41 Astaxanthin, a carotenoid stimulates immune responses via enhancing IFN-γ and IL-2 in primary cultured lymphocytes in vitro and ex vivo. Lin KH, Lin KC, Lu WJ, Thomas PA, Jayakumar T*, Sheu JR. International Journal of Molecular Sciences, 17(1), 44 2016 6.02
42 The pharmacodynamics of antiplatelet compounds in thrombosis treatment. Jayakumar T, Yang CH, Geraldine P, Yen TL, Sheu JR. Expert Opinion on Drug Metabolism & Toxicology 1-18. 2016 4.5
43 Andrographolide stimulates p38 MAPK-Nrf2-HO-1 signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats. Yen TL, Chen RJ, Jayakumar T, Lu WJ, Hsieh CY, Hsu MJ, Yang CH, Chang CC, Lin YK, Lin KH, Sheu JR. Translational Research 170:57-72. 2016 7.012
44 Novel synthetic benzimidazole-derived oligosaccharide, M3BIM, prevents ex vivo platelet aggregation and in vivo thromboembolism. Yen TL, Wu MP, Chung CL, Yang WB, Jayakumar T, Geraldine P, Chou CM, Chang CY, Lu WJ, Sheu JR. Journal of Biomedical Sciences 17, 23(1):26. 2016 8.410
45 Hinokitiol, a Tropolone Derivative, Inhibits Mouse Melanoma (B16-F10) Cell Migration and In vivo Tumor Formation Huang CH, Chang CC, Thomas PA, Jayakumar T*, Sheu JR. European Journal of Pharmacology 746: 148-157 2015 4.432
46 Antiproliferative activity of hinokitiol, a tropolone derivative, is mediated via the inductions of p-JNK and p-PLCγ1 signaling in PDGF-BB-stimulated Yang PS, Wang MJ, Jayakumar T, Chou DS, Ko CY, Hsu MJ, Hsieh CY. Molecules 20, 8198-8212. 2015 4.411
47 Comparative Decline of the Protein Profiles of Nebulin in Response to Denervation in Skeletal Muscle. Wei JH, Chang NC, Chen SP, Geraldine P, Jayakumar T*, Fong TH. Biochemical and Biophysical Research Communication. 1-8 2015 3.575
48 Antrodia camphorata potentiates neuroprotection against cerebral ischemia in rats via down regulation of iNOS/HO-1/Bax and activated caspase-3 and inh Yang PS, Lin PY, Chang CC, Yu MC, Yen TL, Lan CC, Jayakumar T*, Yang CC. Evidence Based Complementary and Alternative Medicine 2014: 1-8. 2015 2.629
49 Hinokitiol exerts anticancer activity through down regulation of MMPs 9/2 and enhancement of catalase and SOD enzymes: In-vivo augmentation of lung hi Huang CH, Jayakumar T, Fong TH, Lu SH, Thomas PA, Choy CS, Sheu JR Molecules 20, 17720-17734 2015 4.411
50 Andrographolide, a novel NF-κB inhibitor, induces vascular smooth muscle cell apoptosis through a SHP-1-PP2A-p38MAPK-p53 cascade. Chen YY, Hsieh CY, Jayakumar T, Lin KH, Chou DS, Lu WJ, Hsu MJ, Sheu JR. Scientific Report 2014 doi:10.1038/srep05651. 2014 4.379
51 Protective effect of Actinopteris radiate (Sw.) link. Against CCl4-induced oxidative stress in albino rats. Manjunath M, Lavanya G, Ravilla S, Jayakumar T, Paresh D, Kjell M, Vijayasarathi Reddy, O. Journal of Ethnopharmacology 154, 744-752. 2014 4.36
52 Ex vivo and in vivo studies of CME-1, a novel polysaccharide purified from the mycelia of Cordyceps sinensis that inhibits human platelet activation b Lu WJ, Chang NC, Jayakumar T, Liao JC, Lin MJ, Wang SH, Chou DS, Thomas PA, Sheu JR. Thrombosis Research 134(6):1301-10 2014 3.944
53 Pleurotus ostreatus, an edible mushroom, enhances glucose 6-phosphate dehydrogenase, ascorbate peroxidase and reduces xanthine dehydrogenase in major Thomas PA, Geraldine P, Jayakumar T*. Pharmaceutical Biology 52(5):646-54. 2014 3.5
54 Brazilin ameliorates high glucose-induced vascular inflammation via inhibiting ROS and CAMs production in human umbilical vein endothelial cells Jayakumar T, Chang CC, Lin SL, Huang YK, Hu CM, Elizebeth AR, Lin SC, Choy CS. Biomed Research International, 2014:403703. 2014 3.411
55 Anti-cancer effects of CME-1, a novel polysaccharide, purified from the mycelia of Cordyceps sinensis against B16-F10 melanoma cells. Jayakumar T, Chiu CC, Wang SH, Chou DS, Huang YK, Sheu JR. Journal of Cancer Research and Therapeutics 10(1):43-9. 2014 1.805
56 Sanguis draconis, a Dragon’s Blood Resin, Attenuates High Glucose-Induced Oxidative Stress and Vascular Inflammation in Human Umbilical Vein Endoth Chang Y, Chang TC, Chang NC, Huang YK, Choy CS, Jayakumar T*. The Scientific World Journal 1-10. 2014 1.6
57 Pharmacology and clinical effect of platonin, a cyanine photosensitizing dye: potential molecular targets. Lee JJ, Chang CF, Sheu JR, Jayakumar T*. Current Pharmaceutical Biotechnology 15 2014 2.837
58 Traditional Chinese medicines and bioactive compounds for the treatment of stroke. Jayakumar T, Elizebeth AR, Yen TL, Sheu JR. Chinese Journal of Integrative Medicine DOI: 10.1007/s11655-014-1782-2. 2014 1.978
59 Hinokitiol, a natural tropolone derivative, offers neuroprotection from thromboembolic stroke in vivo. Jayakumar T, Hsu WH, Yen TL, Luo JY, Kuo YC, Fong TH, Sheu JR. Evidence Based Complementary and Alternative Medicine 2013:840487. 2013 2.629
60 Cinnamophilin isolated from Cinnamomum philippinense protects against collagen degradation in human chondrocytes Lu YC, Hsiao G, Lin KH, Hsieh MS, Jayakumar T, Wu TS, Sheu JR. Phytotherapy Research 27(6):892-9. 2013 5.878
61 A novel antithrombotic effect of sulforaphane via activation of platelet adenylate cyclase: ex vivo and in vivo studies. Jayakumar T, Chen WF, Lu WJ, Chou DS, Hsiao G, Hsu CY, Sheu JR, Hsieh CY. A Journal of Nutritional Biochemistry 24(6), 1086-95. 2013 6.048
62 Serum p-cresyl sulfate predicts cardiovascular disease and mortality in elderly hemodialysis patients Lin CJ, Chuang CK, Jayakumar T, Liu HL, Pan CF, Wang TJ, Chen HH, Wu CJ. Archives of Medical Science 9(4):662-8 2013 3.318
63 Experimental and clinical pharmacology of Andrographis paniculata and its major bioactive phytoconstituent andrographolide. Jayakumar T, Hsieh CY, Lee JJ, Sheu JR. Evidence Based Complementary and Alternative Medicine 2013:846740. 2013 2.629
64 Inhibitory effect of midazolam on MMP-9, MMP-1 and MMP-13 expression in PMA-stimulated human chondrocytes via recovery of NF-κB signaling. Wang JJ, Huan SK, Hsieh KH, Chou HC, Hsiao G, Jayakumar T*, Sheu JR. Archives of Medical Science 9(2), 332-9. 2013 3.318
65 The role of protein-bound uremic toxins on peripheral artery disease and vascular access failure in patients on hemodialysis. Lin CJ, Pan CF, Liu HL, Chuang CK, Jayakumar T, Wang TJ, Chen HH, Wu CJ. Atherosclerosis, 225 (1) 173-9 2012 5.162
66 Chondroprotective role of sesamol by inhibiting MMPs expression via retaining NF-κB signaling in activated SW1353 cells. Lu YC, Jayakumar T, Duann YF, Chou YC, Hsieh CY, Yu SY, Sheu JR, Hsiao G. Journal of Agricultural and Food Chemistry (ACS Journal) 59(9):4969-78 2011 5.279
67 In-vitro and in-vivo antioxidant effects of the oyster mushroom Pleurotus ostreatus. Jayakumar T, Thomas PA, Sheu JR, Geraldine P. Food Research International, 44, 851-861. 2011 7.425
68 An extract of the Pleurotus ostreatus mushroom bolsters the glutathione redox system in various organs of aged rats Jayakumar T, Thomas PA, Ramesh E, Geraldine P. Journal of Medicinal Food 13(4):771-8.: 2010 2.786
69 An extract of the oyster mushroom, Pleurotus ostreatus, increases catalase gene expression and reduces protein oxidation during aging in rats. Jayakumar T, Thomas PA, Isai M, Geraldine P. Journal of Chinese Integrative Medicine (8):774-80. 2010 doi: 10.3736/jcim20100808.
70 In-vitro antioxidant activities of an ethanolic extract of the oyster mushroom, Pleurotus ostreatus. Jayakumar T, Thomas PA, Geraldine P. Innovative Food Science and Emerging Technologies 10:228-234. 2009 7.10
71 Pleurotus ostreatus, an oyster mushroom, decreases the oxidative stress induced by carbon tetrachloride in rat kidneys, heart and brain Jayakumar T, Sakthivel M, Thomas PA, Geraldine P Chemico-Biological Interaction 176(2-3):108-20 2008 5.168
72 Protective effect of an extract of the oyster mushroom, Pleurotus ostreatus, on antioxidants of major organs of aged rats Jayakumar T, Thomas PA, Geraldine P. Experimental Gerontology 42(3):183-91. 2007 4.253
73 Antioxidant activity of the oyster mushroom, Pleurotus ostreatus, on CCl(4)-induced liver injury in rats Jayakumar T, Ramesh E, Geraldine P. Food and Chemical Toxicology 44(12):1989-96. 2006 5.572
74 Stressor- specific induction of heat shock protein 70 in the fresh water prawn Macrobrachium malcolmsonii (H. Milne Edwards) exposed to the pesticides Selvakumar S, Geraldine P, Shanju S, Jayakumar T. Pesticide Biochemistry and Physiology 82:125-132. 2005 4.966

Papers Published in Non UGC Approved Peer Reviewed Journals

S.No Title Name of the Authors as per the order in Paper Journal Name Volume, Issue & Page Nos. Year Impact Factor
1 Comparison of the potency of pterostilbene with NF-κB inhibitors in platelet activation: Mutual activation by Akt-NF-κB signaling in human platelets Hsia CW, W Huang WC, Yang CH, Hsia CH, Jayakumar T, Saravana Bhavan P, Sheu JR, Chiou KR. Applied Sciences 11,13, 1-13. 2021 2.9
2 Reduction of NF-κB Signals in Platelets and Prolongation of Platelet Plug Formation against High Shear Flow in Whole Blood on Human Subject by Columb Hsia CW, Yang CH, Sheu JR, Hsia CH, Tsai CL, Huang WC, Chen TY, Jayakumar T, Saravana Bhavan P, Chang Y, Chang CC. Applied Sciences 10(20), 7323 2021 2.9
3 TQ-6, a Novel Ruthenium Derivative Compound, Possesses Potent Free Radical Scavenging Activity in Macrophages and Rats. Hung KW, Chang CC, Jayakumar T, Velusamy M, Hsia CW, Trang NTT, Chou DS, Hsieh CY, Hsia CH. Applied Sciences 11(3), 1008. 2021 2.9
4 Anti-neuroinflammatory Effect of Newly Synthesized Iridium Metal Complexes in LPS-induced Microglia Cells. Chen YJ, Yuan KC, Jayakumar T, Hsia CH, Hsia CW, Velusamy M, Chou DS, Hou SM. International Journal of Pharmacology -11, 2019 0,8
5 Biofuel and biochemical analysis of Amphora coffeaeformis RR03, a novel marine diatom, cultivated in an open raceway pond. Rajaram MG, Nagaraj S, Manjunath M, Baskara Boopathy A, Kurinjimalar C, Rengasamy R, Jayakumar T, Sheu JR, Li JY. Energies 11, 1341, 1-13. 2018 3.004
6 Inhibitory effect of PDGF-BB and serum-stimulated responses in vascular smooth muscle cell proliferation by hinokitiol via up-regulation of p21 and p5 Li JY, Liu CP, Shiao WC, Jayakumar T, Li YS, Chang NC, Huang SY, Hsieh CY. Archieves of Medical Science. 14(3):579-587. 2018 3.318
7 Possible molecular targets of novel ruthenium complexes in antiplatelet therapy. Jayakumar T, Hsu CY, Khamrang T, Hsia CH, Hsia CW, Manjunath M, Sheu JR. International Journal of Molecular Sciences 19:1-12. 2018 6.02
8 Multi-targeting andrographolide, a Novel NF-κB Inhibitor, as potential therapeutic agent for stroke. Yang CH, Yen TL, Hsu CY, Thomas PA, Sheu JR, Jayakumar T*. International Journal of Molecular Sciences 18:1-14. 2017 6.02
9 Mechanisms of free radical generation in platelets and primary hepatocytes: A novel electron spin resonance study Wang CL, Tsao JT, Jayakumar T, Sheu JR, Chou DS. Molecular Medicine Report 17 (1), 2061-2069 2017 2.952
10 New therapeutic agent against arterial thrombosis: An iridium(III)-derived organometallic compound Hsia CW, Velusamy M, Tsao JT, Hsia CH, Chou DS, Jayakumar T, Lee LW, Li JY, Sheu JR. International Journal of Molecular Sciences 18, 1-16. 2017 6.02
11 Inhibitory Mechanisms of CME-1, a Novel Polysaccharide from the Mycelia of Cordyceps sinensis, in Platelet Activation Chang Y, Hsu WH, Lu WJ, Jayakumar T, Liao JC, Lin MJ, Wang SH, Geraldine P, Lin KH, Sheu JR. Current Pharmaceutical Biotechnology 16(5):451-61. 2015 2.837
12 Inhibitory signaling of 17β-estradiol in platelet activation: the pivotal role of cyclic AMP-mediated nitric oxide synthase activation. Wu GJ, Lee JJ, Chou DS, Jayakumar T, Hsiao G, Chen WF, Sheu JR. European Journal of Pharmacology 649(1-3):140-9. 2015 4.432
13 Potential Advantages of a Combination of Traditional Chinese Medicine, Tao-Hong-Si-Wu-Tang and tissue-Plasminogen Activator for Alleviating Middle Cer Yen TL, Lin KH, Chang CC, Jayakumar T, Fong SH, Sheu JR. Chinese Journal of Integrative Medicine DOI:10.1007/s11655-014-1847-x 2014 1.978
14 Andrographolide, a novel NF-kB inhibitor, inhibits vascular smooth muscle cell proliferation and cerebral endothelial cell inflammation. Chang CC, Duann YF, Yen TL, Chen YY, Jayakumar T, Ong ET, Sheu JR. Acta Cardiologica Sinica 30; 1-8. 2014 2.672
15 Hinokitiol, a natural tropolone derivative, offers neuroprotection from thromboembolic stroke in vivo. Jayakumar T, Hsu WH, Yen TL, Luo JY, Kuo YC, Fong TH, Sheu JR. Evidence Based Complementary and Alternative Medicine 2013:840487 2013 2.629
16 Indoxyl sulfate predicts cardiovascular disease and renal function deterioration in advanced chronic kidney disease. Lin CJ, Liu HL, Pan CF, Chuang CK, Jayakumar T, Wang TJ, Chen HH, Wu CJ. Archives of Medical Research 43(6):451-6 2012 2.235
17 Andrographolide enhances nuclear factor-kappaB subunit p65 Ser536 dephosphorylation through activation of protein phosphatase 2A in vascular smooth mu Hsieh CY, Hsu MJ, Hsiao G, Wang YH, Huang CW, Chen SW, Jayakumar T, Chiu PT, Chiu YH, Sheu JR. Journal of Biological Chemistry 286(8):5942-55. 2011 5.486
18 A novel role of andrographolide, an NF-kappa B inhibitor, on inhibition of platelet activation: the pivotal mechanisms of endothelial nitric oxide syn Lu WJ, Lee JJ, Chou DS, Jayakumar T, Fong TH, Hsiao G, Sheu JR. Journal of Nutritional Biochemistry 89(12):1261-73 2011 6.048
19 Inhibition of vascular smooth muscle cell proliferation by the vitamin E derivative pentamethylhydroxychromane in an in vitro and in vivo study: pivot Hsieh CY, Liu CL, Hsu MJ, Jayakumar T, Chou DS, Wang YH, Hsiao G, Sheu JR. Free Radical Biology and Medicine 49(5):881-93 2010 7.376
20 Cyclic nucleotides and mitogen-activated protein kinases: regulation of simvastatin in platelet activation Lee YM, Chen WF, Chou DS, Jayakumar T, Hou SY, Lee JJ, Hsiao G, Sheu JR. Journal of Biomedical Science 17, 45 2010 8.923
21 Arsenic trioxide-mediated antiplatelet activity: pivotal role of the phospholipase C gamma 2-protein kinase C-p38 MAPK cascade. Lin KH, Chang YF, Fan CY, Jayakumar T, Lee JJ, Chou DS, Hsiao G, Sheu JR. Translational Research 155(2):97-108. 2010 10.171
22 Potent antiplatelet activity of sesamol in an in vitro and in vivo model: pivotal roles of cyclic AMP and p38 mitogen-activated protein kinase. Chang CC, Lu WJ, Chiang CW, Jayakumar T, Ong ET, Hsiao G, Fong TH, Chou DS, Sheu JR Journal of Nutritional Biochemistry 21(12):1214-21 2010 6.048
23 Comparison of the relative activities of inducing platelet apoptosis stimulated by various platelet-activating agents Lin KH, Chang HC, Lu WJ, Jayakumar T, Chou HC, Fong TH, Hsiao G, Sheu JR. Platelets 20(8):575-81. 2009 3.862
24 Green tea catechins, alleviate hepatic lipidemic-oxidative injury in Wistar rats fed an atherogenic diet. Ramesh E, Jayakumar T, Elanchezhian R, Sakthivel M, Geraldine P, Thomas PA. Chemico- Biological Interaction 80(1):10-9. 2009 5.168
25 Epigallocatechin gallate improves serum lipid profile and erythrocyte and cardiac tissue antioxidant parameters in Wistar rats fed an atherogenic diet Ramesh E, Elanchezhian R, Sakthivel M, Jayakumar T, Senthil Kumar RS, Geraldine P, Thomas PA. Fundamental and Clinical Pharmacology 22(3):275-84 2008 2.748

Papers Published in Conference Proceedings

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Books

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Chapters in Books

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1 Nanotechnology-Based Detection and Remediation of Mycotoxins for Food and Agriculture Applications. 1. Manubolu M, Lavanya G, Ludsin SA, Jayakumar T, Fraker M, Kavitha P Nanosensors for Environment, Food and Agriculture Springer Nature 2021 DOI: 10.1007/978-3-030-63245-8_9

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Career Guidance Offered to students

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List of capability enhancement such as Soft skill development, Remedial coaching, Language lab,
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1 2022 M.SC 1 Department of Ecology & Environmental Sciences

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Invited Talks in Conference/Seminar/Workshop/Training Programme

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Conferences/Seminars Organized

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1 Environmental Degradation and Pandemic Department of Geography, Govt. Arts College, Salem, Tamil nadu Online International 26-06-2020 26-06-2020 2020

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