MAHESWARAN MANI Associate Professor

Profile Picture

  • Department of Microbiology
  • School of Life Sciences
  • mahesm@gmail.com, mahes.mib@pondiuni.edu.in

Academic Activity

Academic Activity Picture1

Academic Activity Picture2

Educational Qualification (UG,PG & Higher Order)

S.No Degree Subject/Title of thesis University/Board Year of Passing
1 Post Doctoral Fellow Immunology & Stem Cell Biology Stanford University, CA, USA 2011
2 PhD Microbiology Justus Liebig University, Giessen, Germany 2006
3 MSc Microbiology Bharathidasan University, Trichy, India 2001
4 BSc Botany, Zoology & Chemistry The American College, Madurai, India 1999

Area of Specializaion

Immunology, Stem Cell Biology, Medical Microbiology

Awards / Prizes Conferred

S.No Name / Title of the Award Type Name of the Agency conferred the Award Year of the Award Amount for Cash Award
1 Poster award - Jury Winner INTERNATIONAL India I EMBO course, CCMB, Hyderabad 2022 NA
2 Best Teacher Award REGIONAL Pondicherry University 2022 NA
3 Best Teacher Award REGIONAL Pondicherry University 2019 NA
4 EMBO research leadership course travel award INTERNATIONAL THE WELLCOMETRUST DBT INDIA ALLIANCE 2019 NA
5 Best Teacher Award REGIONAL Pondicherry University 2016 NA
6 Young Investigator Pilot award in cancer biology NATIONAL DBT, Govt of India 2015 NA
7 Best Teacher Award REGIONAL Pondicherry University 2013 NA
8 Magna cum laude (Very good grade) in PhD INTERNATIONAL Justus Liebig University, Germany 2006 NA
9 Post Doctoral Fellowship INTERNATIONAL Stanford University, USA 2006 NA
10 PhD fellowship INTERNATIONAL German Research Foundation (DFG) 2004 NA
11 PhD fellowship INTERNATIONAL DAAD, Germany 2002 NA
12 Rameshkumar Award for best student REGIONAL American College, Madurai 1999 NA

Teaching Experience

S.No Designation Department/Centre Institution
1 Assistant Professor Microbiology Pondicherry University, Puducherry, India
2 Associate Professor Microbiology Pondicherry University, Puducherry, India

Research Experience

S.No Designation Department/Centre Institution Area of Research
1 Post Doctorl Fellow (2006 - 2011) Division of Stem Cell Transplantation, Departmet of Pediatrics Stanford University, CA, USA Immunology, Stem Cell Biology
2 Research Associate (2011-2012) Division of Stem Cell Transplantation, Departmet of Pediatrics Stanford University, CA, USA Immunology, Stem Cell Biology
3 Assistant Professor Microbiology Pondicherry University, Puducherry, India Infection-Immunity, Stem Cell Biology
4 Associate Professor Microbiology Pondicherry University, Puducherry, India Infection-Immunity, Stem Cell Biology

Industry Experience

S.No Designation Company/Corporate Nature of Work

Contribution towards Innovation

S.No Name of the Work/Contribution Specialization Remarks

Patent Details

S.No Title Status Patent Number Year of Award Type Commercialized Status
1 Modulation of Kit Signaling and Hematopoietic Cell Development by IL-4 Receptor Modulation GRANTED US2012/0076797A1 2012 INTERNATIONAL NO

Papers Published in UGC Approved Journals

S.No Title Name of the Authors as per the order in Paper Journal Name Volume, Issue & Page Nos. Year Impact Factor

Papers Published in Non UGC Approved Peer Reviewed Journals

S.No Title Name of the Authors as per the order in Paper Journal Name Volume, Issue & Page Nos. Year Impact Factor
1 Chitosan with pendant (E)-5-((4-acetylphenyl) diazenyl)-6-aminouracil groups as synergetic antimicrobial agents Vijayakumar, B.G et al Journal of materials chemistry B 10 ,.21 pp. 4048-4058 2022 7.5
2 Uracil derivatives as HIV-1 capsid protein inhibitors: design, in silico, in vitro and cytotoxicity studies Ramesh D et al RSC advances 12, 27 &17466-17480 2022 4.036
3 Molecular search for M. lepromatosis among clinically diagnosed leprosy patients in a tertiary care centre in South India. Muthusamy, S., Vilvanathan, S.A., Dhandapany, S.P., Bhagat, V.M., Chadha, V.K., Sivashanmugam, E., Kamalanathan, A., Lakshmanan, S. and Mani, M Lepr Rev 93, pp.89-91 2022 0.5
4 Indole chalcones: Design, synthesis, in vitro and in silico evaluation against Mycobacterium tuberculosis Ramesh D et al European Journal of Medicinal Chemistry 198, 15 July 2020 7.08
5 Kit activates IL-4 receptor and effector STAT6 independent of its cognate ligand in mouse mast cells Sethumadhavan A, Mani M Immunology PMID:31957000 2020 7.39
6 Molecular characterization of Enterococcus faecalis isolates from urinary tract infection and interaction between Enterococcus faecalis encountered De Kathirvel S, Mani M, Gopala Krishnan GK, Sethumadhavan A, Vijayalakshmi T, Ponnan SM, Hanna LE, Mathaiyan M Microb Pathog 2019 Dec 23;140:103944. doi: 10.1016/j.micpath.2019.103944. 2019 3.738
7 Pseudomonas aeruginosa infection stimulates MAPK signaling pathway in human Megakaryocytes Gopi Krishnan Gopala Krishnan Aiswarya Sethumadhavan Pavithra Vellaichamy Maheswaran Mani Microbiology and Immunology May 1. doi: 10.1111/1348-0421.12685 PMID:31041998 2019 2.96
8 Complex chemoattractive and chemorepellent Kit signals revealed by direct imaging of murine mast cells in microfluidic gradient chambers Shamloo A, Manchandia M, Ferreira M, Mani M, Nguyen C, Jahn T, Weinberg K, Heilshorn S. Integr Biol (Camb) Aug;5(8):1076-85 2013 3.29
9 Wiskott-Aldrich syndrome protein is an effector of Kit signaling Maheswaran Mani, Shivkumar Venkatasubrahmanyam, Mrinmoy Sanyal, Shoshana Levy, Atul Butte, Kenneth Weinberg, Thomas Jahn Blood Blood 114 (14), 2900-2908 2009 25.47
10 PII-regulated arginine synthesis controls accumulation of cyanophycin in Synechocystis sp. strain PCC 6803. Maheswaran M, Ziegler K, Lockau W, Hagemann M, Forchhammer K J Bacteriol Apr;188(7):2730-4 2006 3.2
11 The Synechococcus elongatus P signal transduction protein controls arginine synthesis by complex formation with N-acetyl-L-glutamate kinase. Heinrich A, Maheswaran M, Ruppert U, Forchhammer K. Mol Microbiol. Jun;52(5):1303-14. 2004 5.02
12 Complex formation and catalytic activation by the PII signaling protein of N-acetyl-L-glutamate kinase from Synechococcus elongatus strain PCC 7942. Maheswaran M, Urbanke C, Forchhammer K. J Biol Chem Dec 31;279(53):55202-10 2004 4.12
13 Carbon-source-dependent nitrogen regulation in Escherichia coli is mediated through glutamine-dependent GlnB signalling. Maheswaran M, Forchhammer K. Microbiology. Aug;149(Pt 8):2163-72. 2003 2.26

Papers Published in Conference Proceedings

S.No Title Name of the Authors as per the order in Paper Details of Conference Publication Page Nos. Year
1 Paradoxical Dose-Dependent Chemoattractive and Chemorepellent Effects of Kit Ligand (KL) In Mast Cells Revealed In Novel Microfluidic Biochambers. A Shamloo, M Manchandia, M Mani, C Nguyen, T Jahn, KI Weinberg American Society of Hematology Annual Meeting Blood 116 (21), 2010
2 Synergy Between Kit Ligand (KL) and IL-4 In Mast Cells Is Mediated by Cross-Receptor Interactions In Lipid Rafts. Maheswaran Mani, Shivkumar Venkatasubrahmanyam, Yujun Yang, Mark Krampf, Jing Huang, Atul Butte, Thomas Jahn, Kenneth I Weinberg American Society of Hematology Annual Meeting Blood 116 (21), 2010
3 Wiskott-Aldrich Syndrome Protein (WASP) Is An Effector of Kit Signaling Maheswaran Mani, Shivkumar Venkatasubrahmanyam, Mrinmoy Sanyal, Yujun Yang, Jing Huang, Shoshana Levy, Atul Butte, Kenneth I Weinberg, Thomas Jahn American Society of Hematology Annual Meeting Blood 112 (11), 2006

Books

S.No Title of the Book Name of the Authors as per the order in Book Publisher Year ISBN No.

Chapters in Books

S.No Title of the Chapters Name of the Authors Title of the Book Publisher Year ISBN No.
1 Stem Cell Factor induces Mast Cell Degranulation and Proliferation independent of CD81 receptor Maheswaran Mani Smart Healthcare for Disease Diagnosis and Prevention Elsevier 2020 9780128179130
2 PII signal transduction in cyanobacteria: novel mechanisms of global nitrogen control. Karl Forchhammer, Annette Heinrich, Nicole Kloft, Mani Maheswaran and Ulrike Ruppert. Biological Nitrogen Fixation, Sustainable Agriculture and the Environment, Y-P. Wang et al, (eds.), Springer. Printed in the Netherlands 2005 101-4020-3569-1

Edited Books

S.No Title of the Book Name of the Authors as per the order in Book Publisher Year ISBN No.

Ongoing Projects

S.No Title of the Project Sponsored By Period Sanctioned Amount(Rs. Lakh) Year
1 Identification of Signaling Network in Stem Cell Factor and Interleukin-3 Induced Synergistic Proliferation of Human Megakaryocytes ICMR 3 Years 40 2020

Ongoing Consultancy Works

S.No Title of the Consultancy Work Sponsored By Period Sanctioned Amount(Rs. Lakh) Year

Completed Projects

S.No Title of the Project Sponsored By Period Sanctioned Amount(Rs. Lakh) Year
1 Functions of Kit cross receptor signaling in Hematopoietic Stem Cell SERB 3 Years 58 2020
2 Identification and Characterization of Kit Interacting Receptors in Hematopoietic Cells DBT 3 Years 25 2018

Completed Consultancy Works

S.No Title of the Consultancy Work Sponsored By Period Sanctioned Amount(Rs. Lakh) Year

Career Guidance Offered to students

S.No Name of the Scheme No. of Students Competitive Examinations/ Career Counseling No. of Students Passed No. of Students Placed

List of capability enhancement such as Soft skill development, Remedial coaching, Language lab,
Bridge courses, Yoga, Meditation, Personal Counselling and Mentoring etc.,

S.No Name of the Programme/Scheme Date of Implementation No. of Students Enrolled Agencies Involved

Research Guidance - PG

S.No Year Degree No. of Students Awarded Department/Centre
1 2022 M.SC 5 Microbiology
2 2021 M.SC 5 Microbiology
3 2020 M.SC 4 Microbiology
4 2019 M.SC 4 Microbiology
5 2018 M.SC 6 Microbiology
6 2017 M.SC 3 Microbiology
7 2016 M.SC 4 Microbiology
8 2015 M.SC 4 Microbiology
9 2014 M.SC 4 Microbiology
10 2013 M.SC 4 Microbiology

Research Guidance - Ph.D

S.No Student Name Registration Date Registration No. Thesis Title Thesis Submitted Status Thesis Submitted Date Vivavoce Completed Status Date Awarded
1 Aiswarya. K. S 22-08-2014 1400128001 Characterization of Kit Cross Receptor Signaling in Hematopoietic Cells YES 05-08-2020 YES 21-10-2021
2 Sujitha K 29-07-2013 1300128004 Characterization of Immunological response to Enterococcus faecalis infection: an in silico and in vitro approach YES 26-07-2020 YES 27-07-2021
3 Gopi Krishnan G 29-07-2013 1300128001 Characterization of Signaling Pathways in Pseudomonas aeruginosa Infected Megakaryocytes YES 27-06-2019 YES 29-12-2020
4 GOPIKA GOPAN 29-11-2021 2100128003 Mechanism of KL and IL-3 induced signaling in Hematopoietic cells NO NO
5 ANAND KR 23-03-2021 2000128001 Mechanism of KL and IL-4 induced signaling in human megakaryocytes NO NO
6 SUDHAKAR. A 26-03-2021 2000128006 Revealing the Innate Immunity in Pseudomonas encountered human megakaryocytes NO NO
7 Dr. SWAPNA MBBS, MD 30-09-2016 1600128002 Molecular characterization, Proteomic and In silico analysis of pathogenic Mycobacterium species YES 08-03-2023 NO

Research Guidance - Post Doctoral

S.No Scholar Name Designation Funding Agency Fellowship Title Year of Joining Year of Completion

Financial assistance availed to attend conferences / workshops and to pay membership fee
of professional bodies during the year

S.No Conference/ workshop attended for which financial support provided Professional body for which membership fee is provided Amount of Support Place From Date To Date Year

E-Lecture Details

S.No E-Lecture Title Development of e-content/e-learning/delivering Member of Editorial Bodies Reviewer/Referee of
Content/Module Title Institution/Platform Year Weblink

Details of Online Education Conducted

S.No Nature of Online Course No. of Sessions Target Group Date

Invited Talks in Conference/Seminar/Workshop/Training Programme

S.No Title of the Paper Conferences/Seminar/Workshop/Training Programme Organized by Whether International / National / State / Regional / College or University Level From To Year
1 Proteomic analysis of host bacterial interactions Global Microbiology Forum Biocon, Bangalore International 03-04-2019 04-04-2019 2019
2 Exploring Stem cell transplantation to treat leukemia and lymphomas National seminar on emerging trends in cancer & stem cell biology Bharathidasan University, Trichy National 20-03-2018 20-03-2018 2018
3 Kit cross receptor signaling in stem cells National seminar on current topics in biological research Dept of Biochemistry, Pondicherry University National 20-10-2017 20-10-2017 2017
4 Modulation of Kit for effective HSC transplantation National seminar on translational research JIPMER, Puducherry National 04-03-2017 04-03-2017 2017
5 Basics of stem cell biology Refresher course on Bioresources: Prospecting, utilization and conservation SBK College, Arruppukottai, Tamilnadu National 01-11-2017 14-11-2017 2017
6 Kit cross receptor signaling in stem cells International conference on cancer biology SBK College, Arruppukottai, Tamilnadu International 29-09-2016 30-09-2016 2016
7 Kit signaling in HSC fate decision National conference on Better Environment Better Future Holy Cross College, Trichy National 02-08-2016 02-08-2016 2016
8 Methods to study protein-protein interaction DBT sponsored course on Fermentation & Bioseperation methods Dept of Microbiology, Pondicherry University National 02-01-2015 14-01-2015 2015
9 Stem cells in Cancer therapy National seminar on Cancer Biology SBK College, Arruppukottai, Tamilnadu National 23-01-2015 23-01-2015 2015
10 Role of cytokines in health and diseases World Immunology day JIPMER, Puducherry National 29-04-2015 29-04-2015 2015
11 Cancer therapy Reflection 2014 Dept of Physics, Pondicherry University National 21-02-2014 28-02-2014 2014
12 Engineering bacteria to treat cancer National conference in Computation approaches in Microbial biotechnology M.S. University, Thirunelveli National 21-02-2014 21-02-2014 2014
13 Kit signaling in stem cells National conference on Innovations, implementations and controversies of animal biotechnology Bharathidasan University, Trichy National 26-3-2014 26-3-2014 2014
14 Cell therapy using stem cells Advances in Drug design, discovery and development. Anna University BIT Campus, Trichy National 24-07-2014 25-07-2014 2014
15 Stem cell therapy UGC sponsored National conference on Frontiers in Chemistry SBK College, Arruppukottai, Tamilnadu National 15-03-2013 15-03-2013 2013
16 RTK signaling in stem cells Refresher course on Life Sciences UGC Academic Staff college, Pondicherry National 07-01-2013 07-01-2013 2013
17 Kit found its friend. Receptor-Receptor interaction in Stem cells International conference on stem cells & cancer cells ICSCCB, Delhi International 27-10-2012 30-10-2012 2012

Conferences/Seminars Organized

S.No Title of the Programme Sponsors Venue & Duration Whether International / National / State / Regional / College or University Level From To Year

Workshop Organized

S.No Title of the Programme Sponsors Venue & Duration Whether International / National / State / Regional / College or University Level From To Year

Administrative Responsibilities in the Government and Quasi Government Agencies

S.No Name of the Position Agency/Organisation Duration Nature of Duties

Affiliation in Academic Bodies/Societies

S.No Name of the Body/Society Nature of Affiliation Year
1 Indian Immunology Society Life Member 2012
2 Indian Society of Cell Biology Life member 2012
3 The Society of Biological Chemist (India) Life member 2012

Participation & Extension Activities (Academic/Administraion)

S.No Name of the Position (Head, Dean, Co-ordinator, Director, etc.,) Duration Nature of Dutites

Participation & Extension Activities (Co-Curricular)

S.No Name of the Position (NSS, NCC, Warden etc.,) Duration Nature of Dutites

Collaboration with Institution/Industry

S.No Collaborator Name Designation Institution/Industry Type Nature of Collaboration Period of Collaboration Visits to Collaborating
Institution / Industry		 Details of Collaborative Research/Teaching
From Date To Date From Date To Date

Faculty Development Programme Attended (Orientation, Refresher, other Short Term Course during the year)

S.No Title of the FDP Organiser Venue Duration From Date To Date Year

Details of Executive Development Prog/Management Development Prog. conducted

S.No Name of the Programme No. of Participants Venue Duration From Date To Date Year Revenue Generated

Participation in IMPESS, IMPRINT, SPARC, STARS, LEAP Programme etc and DSF Funding Programme

S.No IMPRESS/IMPRINT/SPARC/STARS/LEAP/Others Place From Date To Date Year

Enrolment under ARPIT Programme

S.No Name of the Programme Period of the Programme
From Date To Date
1 Leadership and Governance in Higher Education. Level 2 01-12-2020 31-03-2021