MOHANE COUMAR S Assistant Professor
- Department of Bioinformatics
- School of Life Sciences
- mohane@bicpu.edu.in
Academic Activity
Educational Qualification (UG,PG & Higher Order)
| S.No | Degree | Subject/Title of thesis | University/Board | Year of Passing |
|---|---|---|---|---|
| 1 | Ph.D | Pharmaceutical Sciences | Panjab univerisity | 2003 |
| 2 | M.Pharm | Pharmaceutical Chemistry | Panjab univerisity | 1996 |
| 3 | B.Pharma | Pharmacy | Kerala University | 1994 |
Area of Specializaion
Awards / Prizes Conferred
| S.No | Name / Title of the Award | Type | Name of the Agency conferred the Award | Year of the Award | Amount for Cash Award |
|---|---|---|---|---|---|
| 1 | Best Teacher Award | REGIONAL | Pondicherry University | 2022 | NA |
Teaching Experience
| S.No | Designation | Department/Centre | Institution |
|---|---|---|---|
| 1 | Assistant Professor | Bioinformatics | Pondicherry University |
Research Experience
| S.No | Designation | Department/Centre | Institution | Area of Research |
|---|---|---|---|---|
| 1 | Post Doctoral Fellow | Division of Biotechnology & Pharmaceutical Research | National Health research Institutes, Taiwan | New Drug discovery for Cancer and DIabetes |
| 2 | Post Doctoral Fellow | Department of Chemistry | National Tsing Hua Univeristy, Taiwan | Drug discovery |
| 3 | Research Officer | ICMR Centre for Advanced Research | Regional Research Laboratory, Jammu, India | Herbal Drug Standardization for Clinical Trials |
| 4 | Senior Project Fellow | ICMR Centre for Advanced Research | Regional Research Laboratory, Jammu, India | Herbal Drug Pharmacopeia |
| 5 | Ph.D candidate and Senior Research Fellow | Department of Pharmaceutical Chemistry | University Institute of Pharmaceutical Sciences, Panjab University, India | New Drug discovery for Cardiovascular Diseases |
Industry Experience
| S.No | Designation | Company/Corporate | Nature of Work |
|---|---|---|---|
| 1 | Research Scientist | Ranbaxy Research Laboratory, Gurgaon , India | Drug discovery research |
Contribution towards Innovation
| S.No | Name of the Work/Contribution | Specialization | Remarks |
|---|
Patent Details
| S.No | Title | Status | Patent Number | Year of Award | Type | Commercialized Status |
|---|---|---|---|---|---|---|
| 1 | Fused Multicyclic Compounds as Protein Kinase Inhibitors | GRANTED | KR101718386B1 | 2017 | INTERNATIONAL | NO |
| 2 | Fused Bicyclic and Tricyclic Pyrimidine Compounds as EGFR Kinase Inhibitors | GRANTED | KR101703941B1 | 2017 | INTERNATIONAL | NO |
| 3 | Fused Bicyclic Pyrimidine Compounds as Aurora Kinase Inhibitors | GRANTED | EP2276346B1 | 2016 | INTERNATIONAL | NO |
| 4 | Fused Bicyclic Pyrimidine Compounds as Aurora Kinase Inhibitors | GRANTED | KR101667822B1 | 2016 | INTERNATIONAL | NO |
| 5 | Fused Bicyclic Pyrimidine Compounds as Aurora Kinase Inhibitors | GRANTED | CA2722220C | 2016 | INTERNATIONAL | NO |
| 6 | Fused Multicyclic Compounds as Protein Kinase Inhibitors | GRANTED | US9006252 | 2015 | INTERNATIONAL | NO |
| 7 | Fused Bicyclic Pyrimidine Compounds as Aurora Kinase Inhibitors | GRANTED | AU2009241469 | 2015 | INTERNATIONAL | NO |
| 8 | Fused Bicyclic and Tricyclic Pyrimidine Compounds as EGFR Kinase Inhibitors | GRANTED | JP5781934 | 2015 | INTERNATIONAL | NO |
| 9 | Fused Bicyclic Pyrimidine Compounds as Aurora Kinase Inhibitors | GRANTED | JP5502072 | 2014 | INTERNATIONAL | NO |
| 10 | Fused Multicyclic Compounds as Protein Kinase Inhibitors | GRANTED | EP 2331530 | 2013 | INTERNATIONAL | NO |
| 11 | Fused Bicyclic and Tricyclic Pyrimidine Compounds as EGFR Kinase Inhibitors | GRANTED | US8507502 | 2013 | INTERNATIONAL | NO |
| 12 | Fused Multicyclic Compounds as Protein Kinase Inhibitors | GRANTED | TWI400242 | 2013 | INTERNATIONAL | NO |
| 13 | Fused bicyclic and tricyclic pyrimidine compounds as tyrosine kinase inhibitors | GRANTED | TWI385174 | 2013 | INTERNATIONAL | NO |
| 14 | Fused Bicyclic Pyrimidine Compounds as Aurora Kinase Inhibitors | GRANTED | TWI363627 | 2012 | INTERNATIONAL | NO |
| 15 | Fused Bicyclic Pyrimidine Compounds as Aurora Kinase Inhibitors | GRANTED | US8138194, | 2012 | INTERNATIONAL | NO |
Papers Published in UGC Approved Journals
| S.No | Title | Name of the Authors as per the order in Paper | Journal Name | Volume, Issue & Page Nos. | Year | Impact Factor |
|---|---|---|---|---|---|---|
| 1 | Pan-cancer gene expression analysis: Identification of deregulated autophagy genes and drugs to target them | Sree Karani Kondapuram and Mohane Selvaraj Coumar* | Gene | 844, 146821 | 2022 | 3.9 |
| 2 | Functional inhibition of c-Myc using novel inhibitors identified through “hot spot” targeting. | Ashutosh Singh, Prateek Kumar, Sailu Sarvagalla, Taniya Bharadwaj, Namyashree Nayak, Mohane Selvaraj Coumar, Rajanish Giri, Neha Garg | Journal of Biological Chemistry | 298 (5), 101898 | 2022 | 5.2 |
| 3 | Bacterial effluxome as a barrier against antimicrobial agents: structural biology aspects and drug targeting. | Pownraj Brindangnanam, Ajit Ramesh Sawant, K. Prashanth, and Mohane Selvaraj Coumar*. | Tissue Barrier | 10 (4), 2013695 | 2022 | 4.6 |
| 4 | Deciphering molecular mechanisms of metastasis: Novel insights into targets and therapeutics | Bikashita Kalita and Mohane Selvaraj Coumar* | Cellular Oncology | 44, 751-775 | 2021 | 6.7 |
| 5 | The ribosomal protein eL21 interacts with the protein lysine methyltransferase SMYD2 and regulates its steady state levels | Mohd Imran K Khan, Ramya Chandar M Charles, Reshma Ramachandran, Somlee Gupta, Gayathri Govindaraju, Rashmi Mishra, Arumugam Rajavelu, Mohane Selvaraj Coumar, Sreenivas Chavali, Arunkumar Dhayalan | Biochimica et Biophysica Acta (BBA)-Molecular Cell Research | 1868 (9), 119079 | 2021 | 4.7 |
| 6 | Development of a robust scale-up synthetic route for BPR1K871: a clinical candidate for the treatment of acute myeloid leukemia and solid tumors | Julakanti Satyanarayana Reddy, Chih-Ming Chen, Mohane Selvaraj Coumar, Hsu-Yi Sun, Na Sun, Hsing-Pang Hsieh. | Organic Process Research & Development | 25 (4), 817-830 | 2021 | 3.3 |
| 7 | Mimicking H3 substrate arginine in the design of G9a lysine methyltransferase inhibitors for cancer therapy: a computational study for structure-based | Chandar Charles, M. Ramya; Li, Mu-Chun; Hsieh, Hsing-Pang*; Coumar, Mohane*. | ACS Omega | 6(9), 6100-6111 | 2021 | 3.5 |
| 8 | Investigation of Alpinia calcarata constituent interactions with molecular targets of Rheumatoid Arthritis: docking, molecular dynamics and network ap | Thamizharasi Erusappan, Sree Karani Kondapuram, Sanmuga Priya Ekambaram,,* Mohane Selvaraj Coumar,*. | Journal of Molecular Modeling | 27, 14 | 2021 | 1.8 |
| 9 | Survivin - Caspase protein-protein interaction: experimental evidence and computational investigations to decipher the hot spot residues for drug targ | Sailu Sarvagalla, Tzu-Yu Lin, Sree Karani Kondapuram, Chun Hei Antonio Cheung, and Mohane Selvaraj Coumar*. | Journal of Molecular Strcture | 1229, 129619 | 2021 | 2.7 |
| 10 | Investigation of piperine analogs as P-glycoprotein inhibitors with decreased cross-reactivity with CYP3A4 enzyme | Safiulla Basha Syed, Shu-Yu Lin, Hemant Arya, I-Hsuan Fu, Teng-Kuang Yeh, Mariasoosai Ramya Chandar Charles, Latha Periyasamy, Hsing-Pang Hsieh, and Mohane Selvaraj Coumar.* | Chemical Biology and Drug Design | 97, 51 | 2021 | 2.3 |
| 11 | Multi-objective genetic algorithm for de novo drug design (MoGADDrug) | R. Vasundhara Devi, S. Siva Sathya, Mohane Selvaraj Coumar | Current Computer-Aided Drug Design | 17 (3), 445-457 | 2021 | 1.0 |
| 12 | Multi-objective biofilm algorithm (MOBifi) for de novo drug design with a special focus to anti-diabetic drugs | R. Vasundhara Devi, S. Siva Sathya, Mohane Selvaraj Coumar | Applied Soft Computing | 96, 106655 | 2020 | 5.5 |
| 13 | Enhanced drug retention, sustained release, and anti-cancer potential of curcumin and indole-curcumin analog-loaded polysorbate 80-stabilizied PLGA na | Shamim Akhtar Sufi, Muddasarul Hoda, Sankar Pajaniradje, Sultana Parveen, Selvaraj Mohane Coumar and Rukkumani Rajagopalan | International Journal of Pharmaceutics | 588, 119738 | 2020 | 4.8 |
| 14 | Design of novel ROCK inhibitors using fragment-based de novo drug design approach. | Hemant Arya and Mohane Selvaraj Coumar* | J Molecular Modeling | 26, 249 | 2020 | 1.2 |
| 15 | The SMAC mimetic LCL161 is a direct ABCB1/MDR1-ATPase activity modulator and BIRC5/Survivin expression down-regulator in cancer cells. | Yung-Chieh Chang, Sree Karani Kondapuram, Tsung-Han Yang, Safiulla Basha Syed, Siao Muk Cheng, Tzu-Yu Lin, Yi-Chen Lin, Mohane Selvaraj Coumar Jang-Yang Chang, Euphemia Leung, Chun Hei Antonio Cheung | Toxicology and Applied Pharmacology | 401, 115080 | 2020 | 3.4 |
| 16 | Drug-Like Property Optimization: Discovery of Orally Bioavailable Quinazoline-Based Multi-Targeted Kinase Inhibitors | Shu Yu Lin, Chun-Feng Chang, Mohane Selvaraj Coumar, Pei-Yi Chen, Fu-Ming Kuo, Chun-Hwa Chen, Po-Chu Kuo, Mu-Chun Li, Sing-Yi Wang, An-Siou Li, Chin-Yu Lin, Chen-Ming Yang, Teng-Kuang Yeh and Hsing-Pa | Bioorganic Chemistry | 98, 103689 | 2020 | 3.9 |
| 17 | Identification of novel quinoline inhibitors for EHMT2/G9a through virtual screening | M Ramya Chandar Charles, Arun Mahesh, Shu-YuLin, Hsing-Pang Hsieh, Arunkumar Dhayalan, Mohane Selvaraj Coumar* | Biochimie | 168, 220-230. | 2020 | 3.2 |
| 18 | BIRC5/Survivin is a novel ATG12–ATG5 conjugate interactor and an autophagy-induced DNA damage suppressor in human cancer and mouse embryonic fibrobl | Tzu-Yu Lin, Hsiu-Han Chan, Shang-Hung Chen, Sailu Sarvagalla, Pai-Sheng Chen, Mohane Selvaraj Coumar, Siao-Muk Cheng, Yung-Chieh Chang, Chun-Hui Lin, Euphemia Leung, and Chun Hei Antonio Cheung | Autophagy | 16, 1296–1313 | 2020 | 11.1 |
| 19 | Design of a potent anticancer lead inspired by natural products from traditional Indian medicine | Hemant Arya, C. Suresh Yadav, Shu-Yu Lin, Safiulla Basha Syed, Sathananthan Kannadasan, Hsing-Pang Hsieh, Sorokhaibam Sureshkumar Singh, Padma Raj Gajurel, and Mohane Selvaraj Coumar* | Journal of Biomolecular Structure and Dynamics | 38, 3563-3577 . | 2020 | 3.1 |
| 20 | Repurposing antispasmodic drug Papaverine for the treatment of chronic myeloid leukemia | Phani K Parcha; Sailu Sarvagalla; Cheemala Ashok; S J Sudharshan; Madhu Dyavaiah, Ph.D; Mohane Selvaraj Coumar*; Baskaran Rajasekaran | Pharmacological reports | 73, 615-628 | 2020 | 2.7 |
| 21 | Delineating the active site architecture of G9a lysine methyltransferase through substrate and inhibitor binding mode analysis: a molecular dynamics s | M Ramya Chander Charles, Hsing-Pang Hsieh, Mohane Selvaraj Coumar* | Journal of Biomolecular Structure and Dynamics | 37, 10, 2581-2592. | 2019 | 3.1 |
| 22 | Insights for the design of protein lysine methyltransferase G9a inhibitors | M Ramya Chander Charles, Arunkumar Dhayalan, Hsing-Pang Hsieh, Mohane Selvaraj Coumar* | Future Medicinal Chemistry | 11,9. | 2019 | 4.1 |
| 23 | Chronic myeloid leukemia: Existing therapeutic options and strategies to overcome drug resistance | Vivek Kumar Singh and Mohane Selvaraj Coumar* | Mini Rev Med Chem. | 19 (4), 333-345 | 2019 | 2.5 |
| 24 | Cloning, expression, and purification of the recombinant pro-apoptotic dominant-negative survivin T34A-C84A protein in Escherichia coli. | Shing-Ling Tsai, Yung-Chieh Chang, Sailu Sarvagalla, Shuying Wanga,, Mohane Selvaraj Coumar, Chun Hei Antonio Cheung. | Protein Expression and Purification, | 160, 73-83 | 2019 | 1.4 |
| 25 | Investigations of chemical constituents of clerodendrum colebrookianum in anti-hypertensive drug targets using docking and molecular dynamics simulati | Hemant Arya, Safiulla Basha Syed, Sorokhaibam Sureshkumar Singh, Dinakar R. Ampasala and Mohane Selvaraj Coumar*. | Interdisciplinary Sciences: Computational Life Sciences | 10, 792-804 | 2018 | 1.0 |
| 26 | Can phytochemicals be more specific and efficient at targeting P‑glycoproteins to overcome multi‑drug resistance in cancer cells? In The 150 most | Mohane Selvaraj Coumar and Safiulla Basha Syed | Cancer Commun | 38: 69 | 2018 | 3.8 |
| 27 | In-silico and in-vitro anti-cancer potential of a curcumin analogue (1E, 6E)-1, 7-di (1H-indol-3-yl) hepta-1, 6-diene-3, 5-dione | Shamim Akhtar Sufi, Lakshmi Narayana Adigopula, Safiulla Basha Syed, Victor Mukherjee, Mohane S. Coumar, H. Surya Prakash Rao and Rukkumani Rajagopalan | Biomedicine & Pharmacotherapy | 85, 389–398 | 2017 | 2.8 |
| 28 | Identification of natural inhibitors of Bcr-Abl for the treatment of chronic myeloid leukemia. | Phanikrishna P, Sailu Sarvagalla, Bindu Madhuri, Sankar Pajaniradje, Vinitha Baskaran, Mohane Selvaraj Coumar, & R. Baskaran. | Chemical Biology & Drug Design | 90, 596–608 | 2017 | 2.4 |
| 29 | Reversible testicular toxicity of piperine on male albino rats | Gopichand Chinta, Mohane Selvaraj Coumar and Latha Periyasamy | Pharmacognosy Magazine | 13, S525-S532 | 2017 | 1.0 |
| 30 | Impact of genetic variations in HIV-1 TAT on LTR-mediated transcription via TAR RNA interaction: emergence of virulent strains among HIV-1 infected no | Larance Ronsard, Nilanjana Ganguli, Vivek Kumar Singh, Kumaravel Mohankumar, Tripti Rai, Subhashree Sridharan, Sankar Pajaniradje, Binod Kumar, Suhnrita Chaudhuri, Mohane Selvaraj Coumar, Vishnampetta | Frontiers in Microbiology | 8, 706 | 2017 | 4.0 |
| 31 | Ensemble-based virtual screening: identification of potential allosteric inhibitor of BCR-ABL | Vivek Kumar Singh and Mohane Selvaraj Coumar*. | Journal of Molecular Modeling | 23, 218 | 2017 | 1.4 |
| 32 | PRMT7 interacts with ASS1 and citrullinemia mutations disrupt the interaction | Mamta Verma, Ramya Chandar Charles. M, Baskar Chakrapani, Mohane Selvaraj Coumar, Gayathri Govindaraju, Arumugam Rajavelu, Sreenivas Chavali & Arunkumar Dhayalan | Journal of Molecular Biology | 429, 2278-2289 | 2017 | 4.6 |
| 33 | Identification of a novel leukemic-specific splice variant of DNMT3B and its stability | Singh P, Sailu S, Palchamy E, Coumar MS, Baluchamy | Medical Oncology | 34 (8): 145 | 2017 | 2.6 |
| 34 | Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer. | Safiulla Basha Syed, Hemant Arya, I-Hsuan Fu, Teng-Kuang Yeh, Latha Periyasamy, Hsing-Pang Hsieh, and Mohane Selvaraj Coumar* | Scientific Reports | 7, 7972 | 2017 | 4.3 |
| 35 | Drug repurposing for chronic myeloid leukemia: in silico and in vitro investigation of drugbank database for allosteric bcr-abl inhibitors | Vivek Kumar Singh, Hsin-Huei Chang, Ching-Chuan Kuo, Hui-Yi Shiao, Hsing-Pang Hsieh and Mohane Selvaraj Coumar* | Journal of Biomolecular Structure and Dynamics | 29, 1-16 | 2017 | 3.1 |
| 36 | Discovery of BPR1K871 - a quinazoline based multi-kinase inhibitor for the treatment of aml and solid tumors: rational design, synthesis, in vitro and | Yung Chang Hsu, Mohane Selvaraj Coumar, Wen-Chieh Wang, Hui-Yi Shiao, Yi-Yu Ke, Wen-Hsing Lin, Ching-Chuan Kuo, Chun-Wei Chang, Fu-Ming Kuo, Pei-Yi Chen, Sing-Yi Wang, An-Siou Li, Chun-Hwa Chen, P | Oncotarget | 7, 86239-86256 | 2016 | 5.2 |
| 37 | Disruption of protein–protein interactions: hot spot detection, structure-based virtual screening and in vitro testing for the anti-cancer drug targ | Sailu Sarvagalla, Chun Hei Antonio Cheung, Ju-Ya Tsai, Hsing Pang Hsieh and Mohane Selvaraj Coumar* | RSC Advances | 6, 31947-31959 | 2016 | 3.1 |
| 38 | Therapeutic polymeric nanoparticles and methods of making and using same: a patent evaluation of WO2015036792 | Sailu Sarvagalla, Hsing-Pang Hsieh and Mohane Selvaraj Coumar*. | Expert opinion in Therapeutic Patents | 26 (7), 751-755 | 2016 | 4.9 |
| 39 | P-glycoprotein mediated multidrug resistance reversal by phytochemicals: a review of SAR & future perspective for drug design. | Safiulla Basha Syed, Mohane Selvaraj Coumar* | Current Topics in Medicinal Chemistry | 16(22), 2484-508 | 2016 | 2.5 |
| 40 | BDMC-A, an analog of curcumin, inhibits markers of invasion, angiogenesis, and metastasis in breast cancer cells via NF-ΚB pathway- a comparative stu | Kumaravel Mohankumar, Subhashree Sridharan, Sankar Pajaniradje, Vivek Kumar Singh, Larance Ronsard, Akhil C. Banerjea, Dinesh Babu Somasundaram, Mohane Selvaraj Coumar, Latha Periyasamy, Rukkumani Raj | Biomedicine & Pharmacotherapy | 74, 178-186 | 2015 | 2.8 |
| 41 | Homology modeling of dfg-in fms-like tyrosine kinase (FLT3) and structure-based virtual screening for inhibitor identification. | Yi-Yu Ke, Vivek Kumar Singh, Mohane Selvaraj Coumar, Yung Chang Hsu, WenChieh Wang, Jen-Shin Song, Chun-Hwa Chen, Wen-Hsing Lin, Szu-Huei Wu, John T. A. Hsu, Chuan Shih & Hsing-Pang Hsieh | Scientific Reports | 5:11702 | 2015 | 4.3 |
| 42 | In silico and in vitro investigation of the piperine’s male contraceptive effect: docking and molecular dynamics simulation studies in androgen bin | Gopichand Chinta, Mariasoosai Ramya Chandar Charles, Ivana Klopčič, Marija Sollner Dolenc, Latha Periyasamy,* and Mohane Selvaraj Coumar* | Planta Medica | 81, 804-12 | 2015 | 2.3 |
| 43 | Identification of ligand efficient, fragment-like hits from an hts library: structure-based virtual screening and docking investigations of 2H- and 3H | Sailu Sarvagalla, Vivek Kumar Singh, Yi-Yu Ke, Hui-Yi Shiao, Wen-Hsing Lin, Hsing-Pang Hsieh, John T. A. Hsu, and Mohane Selvaraj Coumar*. | Journal of Computer Aided Molecular Design | 29, 89-100 | 2015 | 3 |
| 44 | Piperine: a comprehensive review of pre-clinical and clinical investigations. | Gopichand Chinta, Safiulla Basha Syed, Mohane Selvaraj Coumar, Latha Periyasamy | Current Bioactive Compounds | 11(3), 156-169 | 2015 | 0 |
| 45 | Structural biology insight for the design of sub-type selective aurora kinase inhibitors. | Sailu Sarvagalla and Mohane Selvaraj Coumar* | Current Cancer Drug Targets | 15, 375-393 | 2015 | 3 |
| 46 | Evolutionary algorithms for de novo drug design – a survey. | R. Vasundhara Devi, S. Siva Sathya, Mohane Selvaraj Coumar* | Applied Soft Computing | 27, 543-552 | 2015 | 3.5 |
| 47 | Apoptotic induction by an analog of curcumin (BDMC-A) in human laryngeal carcinoma cells through extrinsic and intrinsic pathways. | Kumaravel Mohankumar, Sankar Pajaniradje, Subhashree Sridharan, Vivek Kumar Singh, Larance Ronsard, Akhil C Banerjea, Chellakkan S Benson, Mohane Selvaraj Coumar, Latha Periyasamy, Rajagopalan Rukkuma | Cellular Oncology | 37,439-454 | 2014 | 3.8 |
| 48 | Ligand efficiency based approach for efficient virtual screening of compound libraries | Yi-Yu Ke, Mohane Selvaraj Coumar, Hui-Yi Shiao, Wen-Chieh Wang, Chieh-Wen Chen, Jen-Shin Song, Chun-Hwa Chen, Wen-Hsing Lin, Szu-Huei Wu, John T. A. Hsu, Chung-Ming Chang and Hsing-Pang Hsieh. | European Journal of Medicinal Chemistry | 83, 226-235. | 2014 | 4.5 |
| 49 | Virtual screening of traditional Chinese Medicinenese medicine (TCM) database: identification of fragment-like lead molecules for filariasis target as | Hemant Arya and Mohane Selvaraj Coumar*. | Journal of Molecular Modeling | 20, 2266 | 2014 | 1.4 |
| 50 | Mechanism of apoptotic induction in human breast cancer cell, mcf-7, by an analog of curcumin in comparison with curcumin - an in vitro and in silico | Kumaravel Mohankumar, Sankar Pajaniradje, Subhashree Sridharan, Vivek Kumar Singh, Larance Ronsard, Akhil C Banerjea, Chellakkan S Benson, Mohane Selvaraj Coumar, Rukkumani Rajagopalan. | Chemico-Biolgical Interactions | 210, 51-63. | 2014 | 3.1 |
| 51 | Aurora kinase inhibitor patents and agents in clinical testing: an update (2011-13) | Chun Hei Antonio Cheung, Sailu Sarvagalla, Jane Ying-Chieh Lee, Yi-Chun Huang, Mohane Selvaraj Coumar* | Expert opinion in Therapeutic Patents | 24 (9), 1021-1038 | 2014 | 4.9 |
| 52 | Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine aurora kinase inhibitor. | Hui-Yi Shiao, Mohane Selvaraj Coumar, Chun-Wei Chang, Yi-Yu Ke, Ya-Hui Chi, Chang-Ying Chu, Hsu-Yi Sun, Chun-Hwa Chen, Wen-Hsing Lin, Ka-Shu Fung, Po-Chu Kuo, Chin-Ting Huang, Kai-Yen Chang, Cheng-Tai | Journal of Medicinal Chemistry | 56, 5247-5260 | 2013 | 6.3 |
| 53 | Protein kinase inhibitor design by targeting the ASP-PHE-GLY (DFG) motif: the role of the dfg motif in the design of epidermal growth factor receptor | Yi-Hui Peng, Hui-Yi Shiao, Chih-Hsiang Tu, Pang-Min Liu, John Tsu-An Hsu, Prashanth Kumar Amancha, Jian-Sung Wu, Mohane Selvaraj Coumar, Chun-Hwa Chen, Sing-Yi Wang, Wen-Hsing Lin, Hsu-Yi Sun, Yu-Shen | Journal of Medicinal Chemistry | 56, 3889−3903 | 2013 | 6.3 |
| 54 | Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules | Jiun-Ming Wu, Chiung-Tong Chen, Mohane Selvaraj Coumar, Wen-Hsin Lin, Zi-Jie Chen, John T.-A. Hsu, Yi-Hui Peng, Hui-Yi Shiao, Wen-Hsing Lin, Chang-Ying Chu, Jian-Sung Wu, Chih-Tsung Lin, Ching-Pin | Proceedings of the National Academy of Sciences of U S A | 110, E1779-E1787 | 2013 | 9.7 |
| 55 | 3D-QSAR assisted drug design: identification of a potent quinazoline based aurora kinase inhibitor | Yi-Yu Ke, Hui-Yi Shiao, Yung Chang Hsu, Chang-Ying Chu, Wen-Chieh Wang, Yen-Chun Lee, Wen-Hsing Lin, Chun-Hwa Chen, John T. A. Hsu, Chun-Wei Chang, Cheng-Wei Lin, Teng-Kuang Yeh, Yu-Sheng Chao, Mohane | ChemMedChem. | 8, 136-148 | 2013 | 3.2 |
| 56 | Treat cancers by targeting survivin: just a dream or future reality? | Mohane Selvaraj Coumar, Fang-Ying Tsai, Jagat Rakesh Kanwar, Sailu Sarvagalla, Chun Hei Antonio Cheung. | Cancer Treatment Reviews | 39, 802-811 | 2013 | 8.6 |
| 57 | Anti-influenza drug discovery: identification of orally bioavailable quinoline derivative through activity and property guided lead optimization | Jiann-Yih Yeh, Mohane Selvaraj Coumar, Hui-Yi Shiao, Ta-Jen Lin, Yen-Chun Lee, Hui-Chen Hung, Shengkai Ko, Fu-Ming Kuo, Ming-Yu Fang, Yu-Lin Huang, John T. A. Hsu, Teng-Kuang Yeh, Shin-Ru Shih | ChemMedChem. | 7, 1546-1550 | 2012 | 3.2 |
| 58 | Anti-influenza drug discovery: identification of orally bioavailable quinoline derivative through activity and property guided lead optimization | Jiann-Yih Yeh, Mohane Selvaraj Coumar, Hui-Yi Shiao, Ta-Jen Lin, Yen-Chun Lee, Hui-Chen Hung, Shengkai Ko, Fu-Ming Kuo, Ming-Yu Fang, Yu-Lin Huang, John T. A. Hsu, Teng-Kuang Yeh, Shin-Ru Shih | ChemMedChem. | 7, 1546-1550 | 2012 | 3.2 |
Papers Published in Non UGC Approved Peer Reviewed Journals
| S.No | Title | Name of the Authors as per the order in Paper | Journal Name | Volume, Issue & Page Nos. | Year | Impact Factor |
|---|---|---|---|---|---|---|
| 1 | Multi-objective Monkey Algorithm for Drug design | R. Vasundhara Devi, S. Siva Sathya, Nilabh Kumar, Mohane Selvaraj Coumar | Int. J. Intelligent Systems and Applications | 3, 31-41 | 2019 | 0 |
| 2 | Targeting autophagy with small molecules for cancer therapy | Kondapuram Sreekarani, Sailu Sarvagalla, and Mohane Selvaraj Coumar*. | J. Cancer Metastasis and Treatment | 5, 32 | 2019 | 0 |
Papers Published in Conference Proceedings
| S.No | Title | Name of the Authors as per the order in Paper | Details of Conference Publication | Page Nos. | Year |
|---|---|---|---|---|---|
| 1 | GAMOL: genetic algorithm based de novo molecule generator | R. Vasundhara Devi, S. Siva Sathya and Mohane Selvaraj Coumar* | Int. Conf. on Adv. in Comp., Comm., and Inf. Sci. (ACCIS-14). TKM College of Engineering, Kollam, Kerala, India, June 26-28th | 259-265 | 2014 |
Books
| S.No | Title of the Book | Name of the Authors as per the order in Book | Publisher | Year | ISBN No. |
|---|
Chapters in Books
| S.No | Title of the Chapters | Name of the Authors | Title of the Book | Publisher | Year | ISBN No. |
|---|---|---|---|---|---|---|
| 1 | Resources for docking–based virtual screening | Sailu Sarvagalla, Sree Karani Kondapuram, R. Vasundhara Devi and Mohane Selvaraj Coumar* | Molecular Docking for Computer-Aided Drug Design: Fundamentals, Techniques, Resources and Applications | Academic Press (Elsevier) | 2021 | 9780128223123 |
| 2 | Docking–based virtual screening using PyRx tool: autophagy target Vps34 as a case study | Sree Karani Kondapuram, Sailu Sarvagalla, and Mohane Selvaraj Coumar* | Molecular Docking for Computer-Aided Drug Design: Fundamentals, Techniques, Resources and Applications | Academic Press (Elsevier) | 2021 | 9780128223123 |
| 3 | An Overview of Computational Methods, Tools, Servers and Databases for Drug Repurposing | Sailu Sarvagalla, Safiulla Basha Syed and Mohane Selvaraj Coumar* | In Silico Drug Design: Repurposing Techniques and Methodologies | Academic Press (Elsevier) | 2019 | 1522503625 |
| 4 | Protein-protein interactions (PPIs) an alternative to targeting the atp binding site of kinase: in silico approach to identify ppi inhibitors | Sailu Sarvagalla and Mohane Selvaraj Coumar* | Applied Case Studies and Solutions in Molecular Docking-Based Drug Design | IGI Global | 2016 | 1522503625 |
Edited Books
| S.No | Title of the Book | Name of the Authors as per the order in Book | Publisher | Year | ISBN No. |
|---|---|---|---|---|---|
| 1 | Molecular Docking for Computer-Aided Drug Design: Fundamentals, Techniques, Resources and Applications | Mohane S. Coumar | Academic Press (Elsevier) | 2021 | 9780128223123 |
Ongoing Projects
| S.No | Title of the Project | Sponsored By | Period | Sanctioned Amount(Rs. Lakh) | Year |
|---|
Ongoing Consultancy Works
| S.No | Title of the Consultancy Work | Sponsored By | Period | Sanctioned Amount(Rs. Lakh) | Year |
|---|
Completed Projects
| S.No | Title of the Project | Sponsored By | Period | Sanctioned Amount(Rs. Lakh) | Year |
|---|---|---|---|---|---|
| 1 | Computational and biochemical approaches for in-silico screening and discovery of drug-like leads: Anti-diabetic and anti-hypertensive compounds from Clerodendrum spp. occurring in North East India | DBT | 2012- 2015 | 11.83 Lahks | 2015 |
| 2 | Design and discovery of aurora kinase inhibitors as anti-cancer drugs: Application of computer aided drug design | DST | 2012- 2015 | 24.30 Lakhs | 2015 |
| 3 | Targeted anti-cancer agents: Structural Bioinformatics approach to the Design & Development of allosteric Kinase inhibitors | UGC | 2012- 2015 | 10.10 Lahks | 2015 |
Completed Consultancy Works
| S.No | Title of the Consultancy Work | Sponsored By | Period | Sanctioned Amount(Rs. Lakh) | Year |
|---|
Career Guidance Offered to students
| S.No | Name of the Scheme | No. of Students | Competitive Examinations/ Career Counseling | No. of Students Passed | No. of Students Placed |
|---|
List of capability enhancement such as Soft skill development, Remedial coaching, Language lab,
Bridge courses, Yoga, Meditation, Personal Counselling and Mentoring etc.,
| S.No | Name of the Programme/Scheme | Date of Implementation | No. of Students Enrolled | Agencies Involved |
|---|
Research Guidance - PG
| S.No | Year | Degree | No. of Students Awarded | Department/Centre |
|---|---|---|---|---|
| 1 | 2022 | M.TECH | 2 | Bioinformatics |
| 2 | 2022 | M.SC | 4 | Bioinformatics |
| 3 | 2021 | M.TECH | 1 | Bioinformatics |
| 4 | 2021 | M.SC | 3 | Bioinformatics |
| 5 | 2020 | M.TECH | 1 | Bioinformatics |
| 6 | 2020 | M.SC | 3 | Bioinformatics |
| 7 | 2019 | M.TECH | 1 | Bioinformatics |
| 8 | 2019 | M.SC | 3 | Bioinformatics |
| 9 | 2018 | M.TECH | 1 | Bioinformatics |
| 10 | 2018 | M.SC | 1 | Bioinformatics |
| 11 | 2018 | M.TECH | 1 | Bioinformatics |
| 12 | 2017 | M.SC | 2 | Bioinformatics |
| 13 | 2016 | M.TECH | 1 | Bioinformatics |
| 14 | 2016 | M.SC | 3 | Bioinformatics |
| 15 | 2015 | M.SC | 3 | Bioinformatics |
| 16 | 2014 | M.SC | 3 | Bioinformatics |
| 17 | 2013 | M.SC | 5 | Bioinformatics |
| 18 | 2012 | M.SC | 4 | Bioinformatics |
| 19 | 2011 | M.SC | 3 | Bioinformatics |
Research Guidance - Ph.D
| S.No | Student Name | Registration Date | Registration No. | Thesis Title | Thesis Submitted Status | Thesis Submitted Date | Vivavoce Completed Status | Date Awarded |
|---|---|---|---|---|---|---|---|---|
| 1 | Ramya Chandar Charles | 01-08-2013 | PU/CE/E9/PHD/2013-14/ | Computational Investigations of G9a Lysine Methyltransferase for the Design and Discovery of Novel Inhibitors | YES | 22-07-2019 | YES | 10-07-2020 |
| 2 | Safi Bhasha syed | 29-11-2012 | PU/CE/E9/PHD/2012-13/ | Design and Development of Piperine Based P-glycoprotein (P-gp) Inhibitors to Overcome Drug Resistance in Cancer | YES | 08-02-2019 | YES | 30-09-2019 |
| 3 | Shamim Akhtar Sufi | 13-09-2012 | Co-guide | Synthesis, Biological Evaluation and Targeted Delivery of an Indole Analogue of Curcumin for Anti- Cancer Therapy | YES | 07-11-2018 | YES | 06-08-2019 |
| 4 | Hemant Arya | 09-05-2013 | PU/CE/E9/PHD/2012-13/ | Bio-prospecting of natural products for the development of drug-like leads: integrated computational and experimental approaches | YES | 10-09-2018 | YES | 12-04-2019 |
| 5 | Gopi Chand Chinta | 06-02-2013 | R31313 (Co-guide) | Studies on the antifertility effect of Piperine | YES | 16-11-2017 | YES | 14-12-2018 |
| 6 | Vivek Kumar Singh | 24-07-2012 | PU/CE/E9/PHD/2012-13/ | TARGETED ANTICANCER AGENTS: STRUCTURAL BIOINFORMATICS APPROACH TO OVERCOME IMATINIB RESISTANCE IN CHRONIC MYELOID LEUKEMIA | YES | 18-12-2017 | YES | 24-08-2018 |
| 7 | Sarvagalla Sailu | 26-08-2011 | PU/CE/E9/PHD/2011-12/ | Targeting the cell cycle for cancer treatment: Computational approaches for the inhibition of Aurora kinase and Survivin | YES | 06-04-2017 | YES | 12-04-2018 |
| 8 | BRINDANGNANAM P | 25-07-2018 | 1800104004 | Ant-bacterial drug design | NO | NO | ||
| 9 | BIKASHITA KALITA | 05-08-2019 | 1900104002 | Metastatic cancer | NO | NO | ||
| 10 | HIMANSHU TAHILIANI | 29-01-2021 | 2000104003 | Targeting ALDH for cancer treatement | NO | NO | ||
| 11 | Kondapuram Sree Karani | 23-07-2018 | 1800104006 | Autophagy targeted drug discovery | NO | NO |
Research Guidance - Post Doctoral
| S.No | Scholar Name | Designation | Funding Agency | Fellowship Title | Year of Joining | Year of Completion |
|---|
Financial assistance availed to attend conferences / workshops and to pay membership fee
of professional bodies during the year
| S.No | Conference/ workshop attended for which financial support provided | Professional body for which membership fee is provided | Amount of Support | Place | From Date | To Date | Year |
|---|
E-Lecture Details
| S.No | E-Lecture Title | Development of e-content/e-learning/delivering | Member of Editorial Bodies | Reviewer/Referee of | |||
|---|---|---|---|---|---|---|---|
| Content/Module Title | Institution/Platform | Year | Weblink | ||||
Details of Online Education Conducted
| S.No | Nature of Online Course | No. of Sessions | Target Group | Date |
|---|---|---|---|---|
| 1 | Computer-aided Drug design | 2 | M.Pharm (Pharma Chemistry) Students, MTPG&RIHS | 24-02-2022 |
Invited Talks in Conference/Seminar/Workshop/Training Programme
| S.No | Title of the Paper | Conferences/Seminar/Workshop/Training Programme | Organized by | Whether International / National / State / Regional / College or University Level | From | To | Year |
|---|---|---|---|---|---|---|---|
| 1 | Integrated computational and experimental approaches to identify inhibitors for drug efflux transpor | IABSCON-South Zone-2022 & International Symposium on Translational Research | Department of Genetics, University of Mysore | International | 09-09-2022 | 09-09-2022 | 2022 |
| 2 | Drug discovery through computer-aided drug design (CADD) | Faculty Development Program on “Emerging Trends in Biotechnology” | School of Biosciences (SBST), Vellore Institute of Technology | Regional | 31-03-2022 | 31-03-2022 | 2022 |
| 3 | Computer-aided drug design: case studies in anti-cancer drug discovery | Invited Lecture | Centre for Bioseparation & Technology (CBST), Vellore Institute of Technology | University | 18-12-2020 | 18-12-2020 | 2020 |
| 4 | CADD Techniques for Drug Discovery and Case Studies in De novo Drug Design | AICTE-ATAL sponsored Online One Week Faculty Development Program on “ARTIFICIAL INTELLIGENCE IN DRUG DISCOVERY AND DEVELOPMENT | Institute of Pharmaceutical Technology, Sri Padmavathi Mahila Visvavidyalayam, Tirupati | National | 03-11-2020 | 03-11-2020 | 2020 |
| 5 | Computer-aided drug design (CADD) algorithms for drug discovery and application in life science rese | Faculty development program on New frontiers in Artificial Intelligence – Societal perspectives | Sri Padmavathi Mahila Visvavidyalayam, Tirupati | National | 28-11-2019 | 28-11-2019 | 2019 |
| 6 | Application of Bioinformatics in Drug Discovery | Texo Pharma Virtus’19 | Mother Therasa Post Graduate and Research Institute of Health Sciences, Pondicherry | College | 11-10-2019 | 11-10-2019 | 2019 |
| 7 | Principle and application of Bioinformatics in Clinical Oncology | Seminar and Master Class in Molecular Oncology | Dept. Medical Oncology, Regional Cancer Centre, JIPMER | College | 13-07-2019 | 13-07-2019 | 2019 |
| 8 | Natural products inspired drugs discovery: application of computer-aided drug design techniques | National Conference on Drug Discovery and Translational Medicine (DDTM-2019), | Department of Biochemistry & Biotechnology, Annamalai University | National | 14-03-2019 | 16-03-2019 | 2019 |
| 9 | Bioinformatics tools and lab | BRSI sponsored workshop on “Process behind the Drug Discovery” | Department of Biochemistry and Molecular Biology, Pondicherry University | Regional | 03-12-2018 | 03-12-2018 | 2018 |
| 10 | Drug discovery and Computer-aided drug design | Invited Lecture | Department of Bioinformatics, Allagapa University | University | 10-11-2017 | 11-11-2017 | 2017 |
| 11 | Drug discovery and Computer-aided drug design | Invited Lecture | Department of Bioinformatics, Bharathiyar University | University | 19-09-2017 | 19-09-2017 | 2017 |
| 12 | Anti-cancer drug development: Computer-aided drug design (CADD) for lead identification and optimiza | National Workshop On Computational Approaches to Drug Discovery | Centre for Bioinformatics, Pondicherry University | National | 13/12/2017 | 19/12/2017 | 2017 |
| 13 | Drug discovery and Computer-aided drug design | Invited Lecture | Department of Bioinformatics, Allagapa University | University | 04-11-2016 | 05-11-2016 | 2016 |
| 14 | In silico approaches for Drug Repurposing: Targeting Allosteric site of Bcr-Abl for the treatment of | National Seminar on Drug Discovery and Cancer Therapy | Department of Biochemistry and Molecular Biology, Pondicherry University | National | 25/02/2016 | 26/02/2016 | 2016 |
| 15 | Drug discovery and Computer-aided drug design | Invited Lecture | Department of Bioinformatics, Allagapa University | University | 09-10-2015 | 10-10-2015 | 2015 |
| 16 | Computer-aided drug design: Design of anti-filarial agent from natural products | Seminar on Genomics & Proteomics of Disease Vectors and Pathogens | Vector Control Research Centre, Pondicherry | National | 03/11/2015 | 03/11/2015 | 2015 |
| 17 | Drug discovery and Computer-aided drug design | Invited Lecture | Department of Bioinformatics, Allagapa University | University | 21-11-2014 | 22-11-2014 | 2014 |
| 18 | Hit to Lead Evolution: Aurora kinase Inhibitor Development | Drug Design and Industrial Applications | Centre for Bioinformatics, Pondicherry University | National | 09/03/2012 | 09/03/2012 | 2012 |
Conferences/Seminars Organized
| S.No | Title of the Programme | Sponsors | Venue & Duration | Whether International / National / State / Regional / College or University Level | From | To | Year |
|---|---|---|---|---|---|---|---|
| 1 | International Conference cum Workshop on Translational Sciences in Drug Discovery and Development | Indian Science Congress Association (ISCA) | Department of Bioinformatics | International | 25-08-2021 | 26-08-2021 | 2021 |
Workshop Organized
| S.No | Title of the Programme | Sponsors | Venue & Duration | Whether International / National / State / Regional / College or University Level | From | To | Year |
|---|---|---|---|---|---|---|---|
| 1 | NATIONAL SEMINAR CUM WORKSHOP ON DRUG DISCOVERY AND TRANSLATIONAL RESEARCH | DBT | Centre for Bioinformatics, Two days | National | 14-02-2013 | 15-02-2013 | 2013 |
Administrative Responsibilities in the Government and Quasi Government Agencies
| S.No | Name of the Position | Agency/Organisation | Duration | Nature of Duties |
|---|
Affiliation in Academic Bodies/Societies
| S.No | Name of the Body/Society | Nature of Affiliation | Year |
|---|---|---|---|
| 1 | American Society for Microbiology | Global Outreach Member | 2022 |
| 2 | American Chemical Society | Member (Three years) | 2015 |
| 3 | Indian Pharmaceutical Association | Life member | 2012 |
| 4 | Indian Science Congress Association | Life member | 2012 |
Participation & Extension Activities (Academic/Administraion)
| S.No | Name of the Position (Head, Dean, Co-ordinator, Director, etc.,) | Duration | Nature of Dutites |
|---|---|---|---|
| 1 | Member, IEC, Siddha Regional Research Institute, Pondicherry | 3 years | Scrutinize and approve Clinical Trials |
| 2 | Special Invitee, Patent facilitation Committee, IPR cell, Pondicherry University | 2 Years | To provide inputs for IPR related activities of the University |
Participation & Extension Activities (Co-Curricular)
| S.No | Name of the Position (NSS, NCC, Warden etc.,) | Duration | Nature of Dutites |
|---|
Collaboration with Institution/Industry
| S.No | Collaborator Name | Designation | Institution/Industry | Type | Nature of Collaboration | Period of Collaboration | Visits to Collaborating Institution / Industry |
Details of Collaborative Research/Teaching | ||
|---|---|---|---|---|---|---|---|---|---|---|
| From Date | To Date | From Date | To Date | |||||||
Faculty Development Programme Attended (Orientation, Refresher, other Short Term Course during the year)
| S.No | Title of the FDP | Organiser | Venue | Duration | From Date | To Date | Year |
|---|---|---|---|---|---|---|---|
| 1 | Enhancing ICT Skills of Educators for Blended and Online Teaching | Pondicherry University | Online | 10 days | 21-07-2020 | 01-08-2020 | 2020 |
| 2 | Refresher program in Zoology | Pondicherry University | Academic Staff College | 21 days | 08-06-2016 | 28-06-2016 | 2016 |
| 3 | Gene Cloning, Protein Biochemistry, Structure Biology & Bioinformatics | Tata Memorial Centre, Mumbai | Advanced Centre for Treatment, Research and Education in Cancer | 12 days | 04-07-2016 | 15-07-2016 | 2016 |
| 4 | Refresher program in Life Sciences | Pondicherry University | Academic Staff College | 21 days | 19-12-2012 | 08-01-2013 | 2012 |
| 5 | 107th Orientation program | Pondicherry University | Academic Staff College | 28 days | 15-11-2011 | 12-12-2011 | 2011 |
Details of Executive Development Prog/Management Development Prog. conducted
| S.No | Name of the Programme | No. of Participants | Venue | Duration | From Date | To Date | Year | Revenue Generated |
|---|
Participation in IMPESS, IMPRINT, SPARC, STARS, LEAP Programme etc and DSF Funding Programme
| S.No | IMPRESS/IMPRINT/SPARC/STARS/LEAP/Others | Place | From Date | To Date | Year |
|---|
Enrolment under ARPIT Programme
| S.No | Name of the Programme | Period of the Programme | |
|---|---|---|---|
| From Date | To Date | ||