1 |
Repurposing antispasmodic drug Papaverine for the treatment of chronic myeloid leukemia |
Phani K Parcha; Sailu Sarvagalla; Cheemala Ashok; S J Sudharshan; Madhu Dyavaiah, Ph.D; Mohane Selvaraj Coumar*; Baskaran Rajasekaran |
Pharmacological reports |
72 |
2020 |
2.7 |
2 |
Design of a potent anticancer lead inspired by natural products from traditional Indian medicine |
Hemant Arya, C. Suresh Yadav, Shu-Yu Lin, Safiulla Basha Syed, Sathananthan Kannadasan, Hsing-Pang Hsieh, Sorokhaibam Sureshkumar Singh, Padma Raj Gajurel, and Mohane Selvaraj Coumar* |
Journal of Biomolecular Structure and Dynamics |
38, 3563-3577 . |
2020 |
3.1 |
3 |
BIRC5/Survivin is a novel ATG12–ATG5 conjugate interactor and an autophagy-induced DNA damage suppressor in human cancer and mouse embryonic fibrobl |
Tzu-Yu Lin, Hsiu-Han Chan, Shang-Hung Chen, Sailu Sarvagalla, Pai-Sheng Chen, Mohane Selvaraj Coumar, Siao-Muk Cheng, Yung-Chieh Chang, Chun-Hui Lin, Euphemia Leung, and Chun Hei Antonio Cheung |
Autophagy |
16, 1296–1313 |
2020 |
11.1 |
4 |
Identification of novel quinoline inhibitors for EHMT2/G9a through virtual screening |
M Ramya Chandar Charles, Arun Mahesh, Shu-YuLin, Hsing-Pang Hsieh, Arunkumar Dhayalan, Mohane Selvaraj Coumar* |
Biochimie |
168, 220-230. |
2020 |
3.2 |
5 |
Drug-Like Property Optimization: Discovery of Orally Bioavailable Quinazoline-Based Multi-Targeted Kinase Inhibitors |
Shu Yu Lin, Chun-Feng Chang, Mohane Selvaraj Coumar, Pei-Yi Chen, Fu-Ming Kuo, Chun-Hwa Chen, Po-Chu Kuo, Mu-Chun Li, Sing-Yi Wang, An-Siou Li, Chin-Yu Lin, Chen-Ming Yang, Teng-Kuang Yeh |
Bioorganic Chemistry |
98, 103689 |
2020 |
3.9 |
6 |
The SMAC mimetic LCL161 is a direct ABCB1/MDR1-ATPase activity modulator and BIRC5/Survivin expression down-regulator in cancer cells. |
Yung-Chieh Chang, Sree Karani Kondapuram, Tsung-Han Yang, Safiulla Basha Syed, Siao Muk Cheng, Tzu-Yu Lin, Yi-Chen Lin, Mohane Selvaraj Coumar Jang-Yang Chang, Euphemia Leung, Chun Hei Antonio Cheung |
Toxicology and Applied Pharmacology |
401, 115080 |
2020 |
3.4 |
7 |
Multi-objective genetic algorithm for de novo drug design (MoGADDrug) |
R. Vasundhara Devi, S. Siva Sathya, Mohane Selvaraj Coumar |
Current Computer-Aided Drug Design |
https://www.eurekaselect.com/182977/article |
2020 |
1.0 |
8 |
Investigation of piperine analogs as P-glycoprotein inhibitors with decreased cross-reactivity with CYP3A4 enzyme |
Safiulla Basha Syed, Shu-Yu Lin, Hemant Arya, I-Hsuan Fu, Teng-Kuang Yeh, Mariasoosai Ramya Chandar Charles, Latha Periyasamy, Hsing-Pang Hsieh, and Mohane Selvaraj Coumar.* |
Chemical Biology and Drug Design |
https://onlinelibrary.wiley.com/doi/abs/10.1111/cbdd.13758 |
2020 |
2.3 |
9 |
Design of novel ROCK inhibitors using fragment-based de novo drug design approach. |
Hemant Arya and Mohane Selvaraj Coumar* |
J Molecular Modeling |
26, 249 |
2020 |
1.2 |
10 |
Enhanced drug retention, sustained release, and anti-cancer potential of curcumin and indole-curcumin analog-loaded polysorbate 80-stabilizied PLGA na |
Shamim Akhtar Sufi, Muddasarul Hoda, Sankar Pajaniradje, Sultana Parveen, Selvaraj Mohane Coumar and Rukkumani Rajagopalan |
International Journal of Pharmaceutics |
588, 119738 |
2020 |
4.8 |
11 |
Multi-objective biofilm algorithm (MOBifi) for de novo drug design with a special focus to anti-diabetic drugs |
R. Vasundhara Devi, S. Siva Sathya, Mohane Selvaraj Coumar |
Applied Soft Computing |
96, 106655 |
2020 |
5.5 |
12 |
Survivin - Caspase protein-protein interaction: experimental evidence and computational investigations to decipher the hot spot residues for drug tar |
Sailu Sarvagalla, Tzu-Yu Lin, Sree Karani Kondapuram, Chun Hei Antonio Cheung, and Mohane Selvaraj Coumar*. |
Journal of Molecular Strcture |
129619 |
2020 |
2.7 |
13 |
Delineating the active site architecture of G9a lysine methyltransferase through substrate and inhibitor binding mode analysis: a molecular dynamics s |
M Ramya Chander Charles, Hsing-Pang Hsieh, Mohane Selvaraj Coumar* |
Journal of Biomolecular Structure and Dynamics |
37, 10, 2581-2592. |
2019 |
3.1 |
14 |
Cloning, expression, and purification of the recombinant pro-apoptotic dominant-negative survivin T34A-C84A protein in Escherichia coli. |
Shing-Ling Tsai, Yung-Chieh Chang, Sailu Sarvagalla, Shuying Wanga,, Mohane Selvaraj Coumar, Chun Hei Antonio Cheung. |
Protein Expression and Purification, |
160, 73-83 |
2019 |
1.4 |
15 |
Multi-objective Monkey Algorithm for Drug design |
R. Vasundhara Devi, S. Siva Sathya, Nilabh Kumar, Mohane Selvaraj Coumar |
Int. J. Intelligent Systems and Applications |
3, 31-41 |
2019 |
0 |
16 |
Chronic myeloid leukemia: Existing therapeutic options and strategies to overcome drug resistance |
Vivek Kumar Singh and Mohane Selvaraj Coumar* |
Mini Rev Med Chem. |
19 (4), 333-345 |
2019 |
2.5 |
17 |
Insights for the design of protein lysine methyltransferase G9a inhibitors |
M Ramya Chander Charles, Arunkumar Dhayalan, Hsing-Pang Hsieh, Mohane Selvaraj Coumar* |
Future Medicinal Chemistry |
11,9. |
2019 |
4.1 |
18 |
Targeting autophagy with small molecules for cancer therapy |
Kondapuram Sreekarani, Sailu Sarvagalla, and Mohane Selvaraj Coumar*. |
J. Cancer Metastasis and Treatment |
5, 32 |
2019 |
0 |
19 |
Can phytochemicals be more specific and efficient at targeting P‑glycoproteins to overcome multi‑drug resistance in cancer cells? In The 150 most |
Mohane Selvaraj Coumar and Safiulla Basha Syed |
Cancer Commun |
38: 69 |
2018 |
3.8 |
20 |
Investigations of chemical constituents of clerodendrum colebrookianum in anti-hypertensive drug targets using docking and molecular dynamics simulati |
Hemant Arya, Safiulla Basha Syed, Sorokhaibam Sureshkumar Singh, Dinakar R. Ampasala and Mohane Selvaraj Coumar*. |
Interdisciplinary Sciences: Computational Life Sciences |
10, 792-804 |
2018 |
0.8 |
21 |
Impact of genetic variations in HIV-1 TAT on LTR-mediated transcription via TAR RNA interaction: emergence of virulent strains among HIV-1 infected no |
Larance Ronsard, Nilanjana Ganguli, Vivek Kumar Singh, Kumaravel Mohankumar, Tripti Rai, Subhashree Sridharan, Sankar Pajaniradje, Binod Kumar, Suhnrita Chaudhuri, Mohane Selvaraj Coumar, Vishnampetta |
Frontiers in Microbiology |
8: 706 |
2017 |
4.0 |
22 |
Ensemble-based virtual screening: identification of potential allosteric inhibitor of BCR-ABL |
Vivek Kumar Singh and Mohane Selvaraj Coumar*. |
Journal of Molecular Modeling |
23, 218 |
2017 |
1.4 |
23 |
PRMT7 interacts with ASS1 and citrullinemia mutations disrupt the interaction |
Mamta Verma, Ramya Chandar Charles. M, Baskar Chakrapani, Mohane Selvaraj Coumar, Gayathri Govindaraju, Arumugam Rajavelu, Sreenivas Chavali & Arunkumar Dhayalan |
Journal of Molecular Biology |
429, 2278-2289 |
2017 |
4.6 |
24 |
Identification of a novel leukemic-specific splice variant of DNMT3B and its stability |
Singh P, Sailu S, Palchamy E, Coumar MS, Baluchamy |
Medical Oncology |
34 (8): 145 |
2017 |
2.6 |
25 |
Reversible testicular toxicity of piperine on male albino rats |
Gopichand Chinta, Mohane Selvaraj Coumar and Latha Periyasamy |
Pharmacognosy Magazine |
13, S525-S532 |
2017 |
1.0 |
26 |
Identification of natural inhibitors of Bcr-Abl for the treatment of chronic myeloid leukemia. |
Phanikrishna P, Sailu Sarvagalla, Bindu Madhuri, Sankar Pajaniradje, Vinitha Baskaran, Mohane Selvaraj Coumar, & R. Baskaran. |
Chemical Biology & Drug Design |
90, 596–608 |
2017 |
2.4 |
27 |
Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer. |
Safiulla Basha Syed, Hemant Arya, I-Hsuan Fu, Teng-Kuang Yeh, Latha Periyasamy, Hsing-Pang Hsieh, and Mohane Selvaraj Coumar* |
Scientific Reports |
7, 7972 |
2017 |
4.3 |
28 |
Drug repurposing for chronic myeloid leukemia: in silico and in vitro investigation of drugbank database for allosteric bcr-abl inhibitors |
Vivek Kumar Singh, Hsin-Huei Chang, Ching-Chuan Kuo, Hui-Yi Shiao, Hsing-Pang Hsieh and Mohane Selvaraj Coumar* |
Journal of Biomolecular Structure and Dynamics |
29, 1-16 |
2017 |
3.1 |
29 |
In-silico and in-vitro anti-cancer potential of a curcumin analogue (1E, 6E)-1, 7-di (1H-indol-3-yl) hepta-1, 6-diene-3, 5-dione |
Shamim Akhtar Sufi, Lakshmi Narayana Adigopula, Safiulla Basha Syed, Victor Mukherjee, Mohane S. Coumar, H. Surya Prakash Rao and Rukkumani Rajagopalan |
Biomedicine & Pharmacotherapy |
85, 389–398 |
2017 |
2.8 |
30 |
Discovery of BPR1K871 - a quinazoline based multi-kinase inhibitor for the treatment of aml and solid tumors: rational design, synthesis, in vitro and |
Yung Chang Hsu, Mohane Selvaraj Coumar, Wen-Chieh Wang, Hui-Yi Shiao, Yi-Yu Ke, Wen-Hsing Lin, Ching-Chuan Kuo, Chun-Wei Chang, Fu-Ming Kuo, Pei-Yi Chen, Sing-Yi Wang, An-Siou Li, Chun-Hwa Chen, P |
Oncotarget |
7, 86239-86256 |
2016 |
5.2 |
31 |
Disruption of protein–protein interactions: hot spot detection, structure-based virtual screening and in vitro testing for the anti-cancer drug targ |
Sailu Sarvagalla, Chun Hei Antonio Cheung, Ju-Ya Tsai, Hsing Pang Hsieh and Mohane Selvaraj Coumar* |
RSC Advances |
6, 31947-31959 |
2016 |
3.1 |
32 |
Therapeutic polymeric nanoparticles and methods of making and using same: a patent evaluation of WO2015036792 |
Sailu Sarvagalla, Hsing-Pang Hsieh and Mohane Selvaraj Coumar*. |
Expert opinion in Therapeutic Patents |
26 (7), 751-755 |
2016 |
4.9 |
33 |
P-glycoprotein mediated multidrug resistance reversal by phytochemicals: a review of SAR & future perspective for drug design. |
Safiulla Basha Syed, Mohane Selvaraj Coumar* |
Current Topics in Medicinal Chemistry |
16(22), 2484-508 |
2016 |
2.5 |
34 |
Evolutionary algorithms for de novo drug design – a survey. |
R. Vasundhara Devi, S. Siva Sathya, Mohane Selvaraj Coumar* |
Applied Soft Computing |
27, 543-552 |
2015 |
3.5 |
35 |
Structural biology insight for the design of sub-type selective aurora kinase inhibitors. |
Sailu Sarvagalla and Mohane Selvaraj Coumar* |
Current Cancer Drug Targets |
15, 375-393 |
2015 |
3.0 |
36 |
Piperine: a comprehensive review of pre-clinical and clinical investigations. |
Gopichand Chinta, Safiulla Basha Syed, Mohane Selvaraj Coumar, Latha Periyasamy |
Current Bioactive Compounds |
11(3), 156-169 |
2015 |
NA |
37 |
Identification of ligand efficient, fragment-like hits from an hts library: structure-based virtual screening and docking investigations of 2H- and 3H |
Sailu Sarvagalla, Vivek Kumar Singh, Yi-Yu Ke, Hui-Yi Shiao, Wen-Hsing Lin, Hsing-Pang Hsieh, John T. A. Hsu, and Mohane Selvaraj Coumar*. |
Journal of Computer Aided Molecular Design |
29, 89-100 |
2015 |
3.0 |
38 |
In silico and in vitro investigation of the piperine’s male contraceptive effect: docking and molecular dynamics simulation studies in androgen bin |
Gopichand Chinta, Mariasoosai Ramya Chandar Charles, Ivana Klopčič, Marija Sollner Dolenc, Latha Periyasamy,* and Mohane Selvaraj Coumar* |
Planta Medica |
81, 804-12 |
2015 |
2.3 |
39 |
Homology modeling of dfg-in fms-like tyrosine kinase (FLT3) and structure-based virtual screening for inhibitor identification. |
Yi-Yu Ke, Vivek Kumar Singh, Mohane Selvaraj Coumar, Yung Chang Hsu, WenChieh Wang, Jen-Shin Song, Chun-Hwa Chen, Wen-Hsing Lin, Szu-Huei Wu, John T. A. Hsu, Chuan Shih & Hsing-Pang Hsieh |
Scientific Reports |
5:11702 |
2015 |
4.3 |
40 |
BDMC-A, an analog of curcumin, inhibits markers of invasion, angiogenesis, and metastasis in breast cancer cells via NF-ΚB pathway- a comparative stu |
Kumaravel Mohankumar, Subhashree Sridharan, Sankar Pajaniradje, Vivek Kumar Singh, Larance Ronsard, Akhil C. Banerjea, Dinesh Babu Somasundaram, Mohane Selvaraj Coumar, Latha Periyasamy, Rukkumani Raj |
Biomedicine & Pharmacotherapy |
74, 178-186 |
2015 |
2.8 |
41 |
Aurora kinase inhibitor patents and agents in clinical testing: an update (2011-13) |
Chun Hei Antonio Cheung, Sailu Sarvagalla, Jane Ying-Chieh Lee, Yi-Chun Huang, Mohane Selvaraj Coumar* |
Expert opinion in Therapeutic Patents |
24 (9), 1021-1038 |
2014 |
4.9 |
42 |
Mechanism of apoptotic induction in human breast cancer cell, mcf-7, by an analog of curcumin in comparison with curcumin - an in vitro and in silico |
Kumaravel Mohankumar, Sankar Pajaniradje, Subhashree Sridharan, Vivek Kumar Singh, Larance Ronsard, Akhil C Banerjea, Chellakkan S Benson, Mohane Selvaraj Coumar, Rukkumani Rajagopalan. |
Chemico-Biolgical Interactions |
210, 51-63. |
2014 |
3.1 |
43 |
Virtual screening of traditional chinese medicine (TCM) database: identification of fragment-like lead molecules for filariasis target asparaginyl-trn |
Hemant Arya and Mohane Selvaraj Coumar*. |
Journal of Molecular Modeling |
20, 2266 |
2014 |
1.4 |
44 |
Ligand efficiency based approach for efficient virtual screening of compound libraries |
Yi-Yu Ke, Mohane Selvaraj Coumar, Hui-Yi Shiao, Wen-Chieh Wang, Chieh-Wen Chen, Jen-Shin Song, Chun-Hwa Chen, Wen-Hsing Lin, Szu-Huei Wu, John T. A. Hsu, Chung-Ming Chang and Hsing-Pang Hsieh. |
European Journal of Medicinal Chemistry |
83, 226-235. |
2014 |
4.5 |
45 |
Apoptotic induction by an analog of curcumin (BDMC-A) in human laryngeal carcinoma cells through extrinsic and intrinsic pathways. |
Kumaravel Mohankumar, Sankar Pajaniradje, Subhashree Sridharan, Vivek Kumar Singh, Larance Ronsard, Akhil C Banerjea, Chellakkan S Benson, Mohane Selvaraj Coumar, Latha Periyasamy, Rajagopalan Rukkuma |
Cellular Oncology |
37,439-454 |
2014 |
3.8 |
46 |
Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine aurora kinase inhibitor. |
Hui-Yi Shiao, Mohane Selvaraj Coumar, Chun-Wei Chang, Yi-Yu Ke, Ya-Hui Chi, Chang-Ying Chu, Hsu-Yi Sun, Chun-Hwa Chen, Wen-Hsing Lin, Ka-Shu Fung, Po-Chu Kuo, Chin-Ting Huang, Kai-Yen Chang, Cheng-Tai |
Journal of Medicinal Chemistry |
56, 5247-5260 |
2013 |
6.3 |
47 |
Protein kinase inhibitor design by targeting the ASP-PHE-GLY (DFG) motif: the role of the dfg motif in the design of epidermal growth factor receptor |
Yi-Hui Peng, Hui-Yi Shiao, Chih-Hsiang Tu, Pang-Min Liu, John Tsu-An Hsu, Prashanth Kumar Amancha, Jian-Sung Wu, Mohane Selvaraj Coumar, Chun-Hwa Chen, Sing-Yi Wang, Wen-Hsing Lin, Hsu-Yi Sun, Yu-Shen |
Journal of Medicinal Chemistry |
56, 3889−3903 |
2013 |
6.3 |
48 |
Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules |
Jiun-Ming Wu, Chiung-Tong Chen, Mohane Selvaraj Coumar, Wen-Hsin Lin, Zi-Jie Chen, John T.-A. Hsu, Yi-Hui Peng, Hui-Yi Shiao, Wen-Hsing Lin, Chang-Ying Chu, Jian-Sung Wu, Chih-Tsung Lin, Ching-Pin |
Proceedings of the National Academy of Sciences of U S A |
110, E1779-E1787 |
2013 |
9.7 |
49 |
3D-QSAR assisted drug design: identification of a potent quinazoline based aurora kinase inhibitor |
Yi-Yu Ke, Hui-Yi Shiao, Yung Chang Hsu, Chang-Ying Chu, Wen-Chieh Wang, Yen-Chun Lee, Wen-Hsing Lin, Chun-Hwa Chen, John T. A. Hsu, Chun-Wei Chang, Cheng-Wei Lin, Teng-Kuang Yeh, Yu-Sheng Chao, Mo |
ChemMedChem. |
8, 136-148 |
2013 |
3.2 |
50 |
Treat cancers by targeting survivin: just a dream or future reality? |
Mohane Selvaraj Coumar, Fang-Ying Tsai, Jagat Rakesh Kanwar, Sailu Sarvagalla, Chun Hei Antonio Cheung. |
Cancer Treatment Reviews |
39, 802-811 |
2013 |
8.6 |
51 |
Anti-influenza drug discovery: identification of orally bioavailable quinoline derivative through activity and property guided lead optimization |
Jiann-Yih Yeh, Mohane Selvaraj Coumar, Hui-Yi Shiao, Ta-Jen Lin, Yen-Chun Lee, Hui-Chen Hung, Shengkai Ko, Fu-Ming Kuo, Ming-Yu Fang, Yu-Lin Huang, John T. A. Hsu, Teng-Kuang Yeh, Shin-Ru Shih |
ChemMedChem. |
7, 1546-1550 |
2012 |
3.2 |